Comparison of the effect of metabolic acidosis correction of Venous bicarbonate level of 26-28 meq/L with standard correction of 22-24 meq/L to preserve kidney function in patients with non protienuric Chronic Kidney Disease- A Randomised clinical trial

Jawaharlal Institute of postgraduate Medical Education Research0 个研究点目标入组 128 人开始时间: 待定最近更新: 2023年4月3日

试验速览

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•1. All prevalent adult CKD stages 3b, 4 and 5D patients with a minimum follow-up duration of 6 months in Nephrology OPD.
•2. Serum bicarbonate (venous) levels below 22meq/L without bicarbonate supplementation.
•3. Stable kidney function (defined as eGFR fluctuation of less than 2ml/min/1.73m2 in the preceding 3 months)
•4. 24-hour urine protein excretion less than 1g.

•1. Diagnosis of congestive heart failure with New York heart association (NYHA) class 3 or 4 symptoms
•2. History of diabetes or fasting plasma glucose >=126mg/dL and/or post prandial plasma glucose >= 200mg/dL and/or glycosylated hemoglobin (HbA1c) >= 6.5
•3. Use of four or more antihypertensives for blood pressure control
•4. Clinical evidence of volume overload/hypocalcemia/hypercapnea
•5. Serum potassium <3meq/L or >=5.5meq/L
•6. Serum creatinine <2 mg/dL
•7. Decompensated chronic liver disease
•8. Kidney transplant recipient
•9. Receiving Immunosuppressive drug therapy
•10. Active pregnancy
•11. Expected to be initiated on dialysis in the next 6 months as assessed by the treating physician.
•12. Those who had acute kidney injury (according to KDIGO criteria) in the preceding 3 months.
•13. Cystic Kidney disease
•14. Obstructive uropathy

发起方

Jawaharlal Institute of postgraduate Medical Education Research