Visualization of the microcirculation of the nasal mucosa in vivo in different nasal disorders, using Sidestream Dark-Field (SDF) imaging.
Completed
- Conditions
- 20 healthy volunteers will be exposed to either provocation with xylometazoline nasal spray or placebo.
- Registration Number
- NL-OMON24686
- Lead Sponsor
- Academic Medical Center, Amsterdam.Department of Otolaryngology and Clinical Physiology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Patients with active allergic rhinitis, idiopathic rhinitis, chronic rhinosinusitis or nasal polyps;
2. Males or females aged over 18 years with no maximum age;
Exclusion Criteria
1. Smoking;
2. Severe cardiac or pulmonary disorder;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The following parameters will be used to asses the microcirculatory reaction after provocation:<br /><br>Flow in the capillary, venules and arterioles can be scored semi quantitatively or quantitatively:<br /><br>1. Semi quantitative scoring:<br>(0 = no flow, 1 = intermittent flow, 2 = sluggish flow and 3 = continuous flow);<br /><br>2. Quantitative scoring:<br>(velocity, flow, diameter, length, density).
- Secondary Outcome Measures
Name Time Method