Visualization of the microcirculation of the nasal mucosa in vivo in different nasal disorders, using Sidestream Dark Field (SDF) imaging

• Conditions: capillaries; microcirculation; 10046304

• Registration Number: NL-OMON29716
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Patients with active allergic rhinitis, idiopathic rhinitis, chronic rhinosinusitis or nasal polyps;
- Males or females aged over 18 years with no maximum age;
- Approval of the patient*s physician;
- Written informed consent;

Exclusion Criteria

- Smoking;
- Severe cardiac or pulmonary disorder;
- Peripheral vascular disease;
- Medication:
systemic: * blockers, corticosteroids (local and systemic);
any local nasal treatment;
bronchodilatory inhalation medication for pulmonary diseases
> 1000 *g/day;
- Cystic fibrosis, Immotile cilia syndrome, Rendu-Osler-Weber disease, vasculitis;
- Cocaine and/or alcohol abuse.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The following parameters will be used to asses the microcirculatory function in<br /><br>patients with allergic rhinitis, idiopathic rhinitis, chronic rhino sinusitis<br /><br>and nasal polyps:<br /><br><br /><br>Flow in the capillary, venules and arterioles can be scored semi quantitatively<br /><br>or quantitatively:<br /><br><br /><br>*Semi quantitative scoring:<br /><br>(0 = no flow, 1 = intermittent flow, 2 = sluggish flow and 3 = continuous flow)<br /><br><br /><br>*Quantitative scoring:<br /><br>velocity, flow, diameter, length, density</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>