GLUCOZOND: the impact of dietary intake on continous glucose levels in healthy people

• Conditions: - endocrine disorders; diabetes complications- nutritional disorders and metabolic diseases; glucose metabolism disorders (incl. diabetes mellitus)

• Registration Number: NL-OMON26257
• Lead Sponsor: Strategic Program RIVM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

BMI 18.5-30 kg/m2
- 18-65 years old
- Subjectively health

Exclusion Criteria

- Illiteracy
- Not being able to give informed consent
- Do not have a doctor
- Use of medicines that can influence glucose levels: such as beta-adrenergic receptor antagonists ('betablockers')
- Pregnancy, breastfeeding, women who are actively trying to conceive
- Acute and / or chronic disease that prevents the test subject from adhering to the research protocol.
- Metabolic and / or hormonal disorders, such as diabetes mellitus
- Swallowing problems, delayed stomach emptying
- Allergies for the standard snack, such as gluten intolerance
- Practicing extreme sports (for example, marathon, triathlon)
- Practicing a very physically demanding job such as in construction.
- Smoking
- Known allergic skin reaction during the use of continuous glucose monitoring or patches in general

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The continuous glucose values are determined with Dexcom G6 glucose monitors that the subjects carry with them for 10 days. The primary endpoint of the study is the difference in the incremental area under the glucose response curve: the incremental area under the curve (iAUC) at different times of the day around the consumption of standardized snacks. During the entire 10-day period, the test subjects keep a food diary through an app.

Secondary Outcome Measures

Name	Time	Method
To explore the relationship with physical activity and nutrition, the test subjects also wear an ActiGraph wGT3X BT accelerometer.<br><br>