Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait
- Conditions
- Parkinson Disease
- Interventions
- Procedure: Chronic Subthalamic nucleus stimulationProcedure: Unilateral reduction of stimulation
- Registration Number
- NCT02704195
- Lead Sponsor
- University Hospital, Grenoble
- Brief Summary
Impact of unilateral modulation of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease
- Detailed Description
Unilateral modulation of subthalamic stimulation and its impact on freezing of gait in Parkinson's disease will be studied.
In a cross-over, doubleblind, randomized study, a 30% reduction of stimulation intensity of the less impacted side will be compared with chronic treatment with regard to frequency and duration of freezing of gait episodes.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 12
Patients affiliated to social security Patient with idiopathic parkinson's disease, with deep brain stimulation since at least one year Freezing of gait Able to give inform consent
Patient under guardianship, legal guardianship Psychosis Severe depression Severe cognitive troubles (Mattis < 130) Other neurologic or medical pathology interfering with gait
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Chronic Subthalamic nucleus stimulation Chronic Subthalamic nucleus stimulation This arm is the reference, with the best stimulation parameters Unilateral reduction of stimulation Unilateral reduction of stimulation 30% unilateral reduction of Subthalamic nucleus stimulation
- Primary Outcome Measures
Name Time Method improvement of Freezing of gait 1 month after new stimulation parameters the improvement will be measure with a composite score of items 12 + 13 on UPDRS II and items 10+11 on UPDRS III,
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Grenoble
🇫🇷Grenoble, France