Subthalamic Nucleus, Akinesia and Parkinson's Disease
Not Applicable
Recruiting
- Conditions
- Parkinson's Disease
- Interventions
- Procedure: Bilateral subthalamic stimulation
- Registration Number
- NCT01682668
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN stimulation improves motor signs in PD patients .
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Frequency of subthalamic stimulation Bilateral subthalamic stimulation Comparison between healthy controls and PD patients (non-operable patients or who will be operated or already operated)
- Primary Outcome Measures
Name Time Method Firing rate of the subthalamic neurons During surgery for bilateral STN stimulation Changes in the neuronal activity of the STN before, during and after the execution of an arm movement
- Secondary Outcome Measures
Name Time Method Evoked related potentials of the STN 3-5 days after surgery for bilateral STN stimulation Local-field potentials recordings with DBS electrodes when performing the execution of an arm movement or gait initiation
Biomechanical parameters of gait initiation 6 months Gait initiation parameters by using a forceplate and EMG recordings
Trial Locations
- Locations (2)
CIC-GHPS
🇫🇷Paris, France
Groupe Hospitalier Pitie-Salpêtrière
🇫🇷Paris, France