Effects of probiotics on rheumatoid knee joint required total knee joint arthroplasty
Not Applicable
- Conditions
- rheumatoid arthritis
- Registration Number
- JPRN-UMIN000004054
- Lead Sponsor
- Center for Rheumatic Diseases, Yokohama City University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
1.Patients with allergy to milk or foods which contain lactobacillus 2.Patients with critical complications in heart, kidney, liver, and blood disorder 3.Patients considered to be ineligible by the responsible researcher or assigned researcher
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentration of hyaluronic acid (HA) in joint fluid and serum.
- Secondary Outcome Measures
Name Time Method DAS28, mHAQ. The concentration of MMP-3 and TNF-alpha in joint fluid. The concentration of MMP-3 in serum. The titer of anti-E-coli antibody