The effect of synbiotics in the treatment of patients with halitosis

Phase 2

• Conditions: Halitosis.; Halitosis; R19.6

• Registration Number: IRCT20200915048726N2
• Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

Age range from 18 to 60 years
Halitosis with an Organoleptic (OLT) score of two and above, which is subjectively determined by the doctor and objectively by the person herself
Informed consent

Exclusion Criteria

The presence of infection and active inflammation of the nose and pharynx in examination and history
History of sensitivity to probiotics
The presence of infection and active inflammation of the mouth and teeth in examination and history
Advanced renal failure
Cirrhosis of the liver
The patient's lack of consent to participate or the desire to withdraw from the study
Use of immunosuppressive drugs
Pregnancy and breastfeeding
Use of mouthwash and mouth fresheners during the study
Patients with typical symptoms GERD or peptic ulcer
Use of antibiotics in the last month
Recent surgery

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of halitosis. Timepoint: before treatment (day zero); Day 15; Day 30 (end of treatment); Day 45 and Day 60. Method of measurement: based on organoleptic score.

Secondary Outcome Measures

Name	Time	Method
Side effects. Timepoint: before treatment (day zero); Day 15; Day 30 (end of treatment). Method of measurement: evaluation checklist.;Remission rate. Timepoint: before treatment (day zero); Day 15; Day 30 (end of treatment); Day 45 and Day 60. Method of measurement: based on organoleptic score.