investigation of the effect of propranolol on sympathetic skin response and bone mass density of burn patients

Not Applicable

• Conditions: Burn.; T20-32; Burns and corrosions

• Registration Number: IRCT2016111930974N1
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

We will include 18 to 50 years old patients experiencing electrical injury 15 days to 3 months prior to the study. Exclusion criteria are as follows: positive history of joint or bone disease; neuropathy (central or peripheral); diabetes mellitus or consumption of any drug affecting the autonomic nervous system; any cast; skin lesion, skin graft, or scar at the sites of SSR recording or stimulus (palms, soles, wrists, or ankles) that make technical problems for SSR recording; contraindications of propranolol administration such as bronchial asthma, pronounced bradycardia, manifest heart failure, second and third degree heart block, hypersensitivity to propranolol. Any patient with evidence of peripheral neuropathy on 4 limb electrophysiologic study (done at the beginning of the study after filling in the written informed consent).

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bone mass desitometery. Timepoint: Before study and 3 months, 9 months after study. Method of measurement: Bone mass densitometery.;Sympathetic skin response. Timepoint: Before study and 3 months, 9 months after study. Method of measurement: SSR.

Secondary Outcome Measures

Name	Time	Method
Decreased blood pressure. Timepoint: Before and every 2 weeks after study. Method of measurement: Mesurment of blood pressure.