Comparison of surgical stress response in standard pressure pneumoperitoneum versus isobaric pneumoperitoneum (gasless) in patients undergoing Laparoscopic cholecystectomy: A Randomized Controlled Study.
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Maulana Azad medical College
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Percentage change in hs-CRP in Laparoscopic Cholecystectomy with standard pressure pneumoperitoneum and isobaric pneumoperitoneum(gasless) at preoperative (8 am morning of surgery), immediate postoperative (during skin closure), and postoperative (2 hours and 24 hours after surgery) period.
Overview
Brief Summary
To compare surgical stress response in standard pressure pneumoperitoneum versus isobaric pneumoperitoneum (gasless) in patients undergoing laparoscopic cholecystectomy in terms of hs-CRP.
PRIMARY OBJECTIVES: To compare surgical stress response in terms of hs-CRP in both groups.
SECONDARY OBJECTIVES:
To compare ACTH, Cortisol, IL-6, Neutrophil:Lymphocyte ratio in both groups.
To compare postoperative pain and duration of hospital stay in both groups.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •18-65 years.
Exclusion Criteria
- •Pregnancy and lactation.
- •Known case of Rheumatoid Arthritis, Inflammatory Bowel Disease.
- •BMI above 30 kg/m
- •Empyema Gallbladder.
Outcomes
Primary Outcomes
Percentage change in hs-CRP in Laparoscopic Cholecystectomy with standard pressure pneumoperitoneum and isobaric pneumoperitoneum(gasless) at preoperative (8 am morning of surgery), immediate postoperative (during skin closure), and postoperative (2 hours and 24 hours after surgery) period.
Time Frame: Preoperative (8 am morning of surgery), immediate postoperative (during skin closure), and postoperative (2 hours and 24 hours after surgery) period.
Secondary Outcomes
- Comparison of ACTH, Cortisol, IL-6, Neutrophil:Lymphocyte ratio(Early morning of surgery, 2 hours and 24 hours after surgery)
Investigators
Soukat Ali Khan
Maulana Azad medical College