Correlation Between Urine UACR and Postoperative Neurocognitive Disorder in Elderly Patients With Non-cardiac Surgery
- Conditions
- Postoperative Cognitive DysfunctionDelirium
- Interventions
- Diagnostic Test: Neuropsychological tests
- Registration Number
- NCT03860714
- Lead Sponsor
- Han Yuan
- Brief Summary
This study intends to evaluate the relationship between urinary albumin/creatinine ratio and postoperative neurocognitive impairment in elderly non-cardiac surgery patients. The results of the study are to identify risk factors, screen high-risk populations to improve clinical evidence, early detection and early treatment.And reducing the burden of PNCD on patients and their families, hospitals and public resources.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 400
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Non-cardiac surgery patients;
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Age is greater than or equal to 60 years old; ③Han Nationality, mother tongue is chinese;
④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
⑤The people signed informed consent.
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The diagnosis of preoperative delirium；
- The diagnosis Unstable hypertension（Such as：pheochromocytoma or aortic dissection）； ③Severe chronic obstructive pulmonary disease or congestive heart failure； ④Severe liver and kidney dysfunction;
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description study group Neuropsychological tests 400 Male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University \[Jiangsu China\].We do the neuropsychological tests,MMSE,CCI，CDR,QoR-40,GDS,CAGE Alcoholism Questionnaire，Pure Tone Audiometry，blood albumin、hemoglobin content、ALT、AST、BUN、Cr、serum folic acid、vitamin B12、homocysteine and branched chain amino acid content 1 day before the surgery（baseline）； 1 day before the surgery（baseline）； Confusion Assessment Method（CAM)，NRS once before discharge from PACU and 1、2、3 days after surgery twice a day； QoR-40 1 day after surgery； Neuropsychological tests and MMSE 6±1 days and one month after surgery.
- Primary Outcome Measures
Name Time Method Confusion Assessment Method（CAM) afternoon of the 3st day after surgery Confusion Assessment Method to measure delirium
- Secondary Outcome Measures
Name Time Method Mini-Mental score examination (MMSE) and Neuropsychological tests one month after surgery Mini-Mental score examination (MMSE) and Neuropsychological tests to measure cognitive function, including the Trail
serum branched chain amino acid content 1 day before surgery(baseline) Record preoperative serum branched chain amino acid content
Quality of Recovery Score - 40 (QoR-40) 1 day after surgery Quality of recovery will be evaluated by Quality of Recovery 40 (QoR40),which assesses five dimensions of recovery (physical comfort,emotional state, physical independence , physiological support and pain ). Each item is rated on a five-point Likert scale: none of the time, some of the time, usually, most of the time, and all the time. The total score on the QoR40 ranges from 40 (poorest quality of recovery) to 200 (best quality of recovery).
serum vitamin B12 levels 1 day before surgery(baseline) Record preoperative serum vitamin B12 levels
serum homocysteine content 1 day before surgery(baseline) Record preoperative serum homocysteine content
Numerical Rating Scale（NRS） afternoon of the 3st day after surgery Evaluate the severity using numerical rating scale（NRS）, where zero mean no pain and 10 the worst imaginable pain.
Mini-Mental score examination (MMSE) 1 day before surgery(baseline) Mini-Mental score examination \[MMSE\] used for screening of dementia
serum folic acid levels 1 day before surgery(baseline) Record preoperative serum folic acid levels
Trial Locations
- Locations (1)
Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University
🇨🇳Xuzhou, Jiangsu, China