Correlation of Peritoneal Fluid CA-125 Levels With Postoperative Tumor Histology

Not Applicable

Completed

• Conditions: Endometrial Carcinoma
• Interventions: Diagnostic Test: abdominal fluid CA-125 levels test

• Registration Number: NCT04830332
• Lead Sponsor: Erdemli State Hospital

Brief Summary

In this prospective study, we aimed to investigate whether serum and abdominal washing fluid CA-125 levels correlated with postoperative histopathological parameters in patients with endometrial carcinoma.

Detailed Description

Endometrial cancer was diagnosed with histopathological examination of the samples obtained by dilatation and curettage. Preoperative serum CA-125 levels were determined in all patients. Serum and abdominal washing fluid CA-125 levels were measured with a double antibody sandwich immunoenzymatic method, using Beckman Coulter DXI (Ireland) analyzer. In addition to routine preoperative investigations, MRI was done in patients who were thought to have an extension outside the uterus.

During surgery, abdominal exploration was performed first, and then an abdominal fluid sample was obtained for cytological examination and measurement of CA-125 level. One hundred milliliters of normal saline was used as the abdominal washing liquid to obtain the sample for CA-125 measurement. Subsequently, total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH + BSO) were performed.

Study Timeline

• Study Start: 2011-12-01
• Primary Completion: 2012-12-01
• Study Completion: 2012-12-01
• Status Verified: 2021-03
• Study First Submitted: 2021-03-31
• Study First Submitted QC: 2021-03-31
• Last Update Submitted: 2021-03-31
• Study First Posted: 2021-04-05
• Last Update Posted: 2021-04-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• Women with endometrial carcinoma

Exclusion Criteria

• Previous history of any other malignancy
• Endometriosis
• Diagnosed with pelvic infection or with any other potential disease such as acute pancreatitis, colitis, diverticulitis, pericarditis, polyarteritis nodosa, Sjögren's syndrome and SLE

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Study group	abdominal fluid CA-125 levels test	Women with endometrial carcinoma

Primary Outcome Measures

Name	Time	Method
Abdominal washing fluid CA-125 levels	One year

Trial Locations

Locations (1)

Antalya Training and Reseacrh Hospital; 🇹🇷 Antalya, Turkey