Swiss Postpartum Hypertension Cohort

Recruiting

• Conditions: Postpartum Hypertension (PPHT)

• Registration Number: NCT04690660
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

This open label, prospective observational, single-center registry is to study short-, intermediate-and long-term course of postpartum hypertension and predictors/risk factors associated with long term cardiovascular and renal risk.

Current disease management strategies will be evaluated.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-04
• Study First Submitted: 2020-12-15
• Study First Submitted QC: 2020-12-27
• Study First Posted: 2020-12-31
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-21
• Last Update Posted: 2025-05-28
• Primary Completion: 2030-05
• Study Completion: 2030-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 480

Inclusion Criteria

• all women with hypertensive disorders of pregnancy
• postpartum hypertension (blood pressure measurements of systolic ≥140 and/or diastolic ≥ 90mmHg or antihypertensive therapy within the first 14 days after delivery)
• women with preexisting hypertension or
• women on antihypertensive medication

Exclusion Criteria

• delivery > 14 days
• lack of consent to participate in the study, language barriers or lack of general understanding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of persistent hypertension defined by 24 hours BP measurement	through study completion, an average of 5 years	Frequency of persistent hypertension defined by 24 hours BP measurement
Frequency of persistent hypertension defined by office blood pressure measurement (OBPM, AOBPM)	through study completion, an average of 5 years	Frequency of persistent hypertension defined by office blood pressure measurement (OBPM, AOBPM)
Frequency of microalbuminuria	through study completion, an average of 5 years	Frequency of microalbuminuria
Frequency of damage to the retina of the eyes (retinopathy)	through study completion, an average of 5 years	Frequency of damage to the retina of the eyes (retinopathy)
Signs of hypertensive heart disease	up to 24 months	Signs of hypertensive heart disease at transthoracic echocardiography determined by left ventricular hypertrophy (LVH)
Frequency of dyslipidemia	through study completion, an average of 5 years	Frequency of dyslipidemia
Frequency of prediabetes/diabetes	through study completion, an average of 5 years	Frequency of prediabetes/diabetes

Trial Locations

Locations (1)

Medical Outpatient Department and Hypertension Clinic, University Hospital Basel; 🇨🇭 Basel, Switzerland