Molecular detection of pulmonary oxygen toxicity using exhaled breath analysis after hyperbaric hyperoxic exposure.

Completed

• Conditions: beroepsmatige blootstelling aan fysische factoren; chronic oxygen poisoning; late onset oxygen poisoning.; 10024967

• Registration Number: NL-OMON44355
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Adults
- Non-smoking
- Fit to dive according to the European Diving Technology Committee (EDTC) standards. (includes lung function tests such as DLCO % reference ERS/ATS > 70%)
- Certified Navy Divers (only applicable to wet-dives)
- Certified hyperbaric nurses and physicians (only applicable to dry-dives)

Exclusion Criteria

- If one on the inclusion criteria is not met
- Recent lower respiratory tract infection and/or flue
- Daily use of alcoholic beverages

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Will an exposure to a PO2 of 190 kPa (100% oxygen at 9 msw) during 60<br /><br>minutes in an immersed setting lead to changes in EB compared a PO2 of 40 kPa<br /><br>(21% oxygen at 9 msw)?<br /><br><br /><br>2. Will a repetitive exposure to a PO2 of 250 kPa (100% oxygen at 15 msw,<br /><br>similar to HBOT) during 90 minutes in a dry setting lead to changes in EB?<br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>a. Difference in EB measured by SpinoNose or GCMS.<br /><br>b. Time interval post-dive which gives the best markers for POT.</p><br>