Measurement of non-invasive mitochondrial oxygenation and metabolism in healthy volunteers over time

• Conditions: Mitochondriale oxygenatie; cellular oxygen metabolism; Mitochondrial function

• Registration Number: NL-OMON45862
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 9

Inclusion Criteria

* 18-35 years of age

Exclusion Criteria

* Mentally disabled
* Presence of mitochondrial disease
* Porphyria
* History of atrial or ventricular arrhythmia
* (Family) history of myocardial infarction or stroke under the age of 65 years
* Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a complex bundle branch block
* Hypertension (defined as RR systolic > 160 or RR diastolic > 90)
* Hypotension (defined as RR systolic < 100 or RR diastolic < 50)
* History of renal impairment

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>mitochondrial oxygen concentration (mitoPO2) en oxygen disappearance rate (ODR)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Heart rate<br /><br>Non invasive bloedpressure<br /><br>respiratory rate<br /><br>Temperature<br /><br>Sickness score</p><br>