Flow versus Pressure Controlled Ventilation in patients with moderate to severe Acute Respiratory Distress Syndrome
- Conditions
- moderate to severe Acute Respiratory Distress Syndrome and pulmonary inflammatory disease10024967
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 28
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- 18 years or older;
- Provided written informed consent;
- Undergoing controlled mechanical ventilation via an endotracheal tube;
- Meeting all criteria of the Berlin definition of ARDS:
o Hypoxic respiratory failure within 1 week of a known clinical insult or new
or worsening respiratory symptoms
o Bilateral opacities on X-ray or CT-scan not fully explained by effusions,
lobar/lung collapse (atelectasis), or nodules
o Respiratory failure not fully explained by cardiac failure or fluid overload.
o Oxygenation: moderate ARDS P/F ratio between 101-200 mmHg, severe ARDS PF
ratio <= 100mmHg, both with PEEP >= 5 cmH2O.
- Development of ARDS <= 72 uur
- Intubated
- Severe sputum stasis or production requiring frequent bronchial suctioning
(more than 5 times per nurse shift) - Untreated pneumothorax (i.e. no pleural
drainage) - Hemodynamic instability defined as a mean arterial pressure below
60mmHg not responding to fluids and/or vasopressors or a noradrenalin dose >
0.5mcrg/kg/min - High (>15 mmHg) or instable (an increase in sedation or
osmotherapy is required) intracranial pressure - An inner tube diameter of 6mm
or less - Anticipating withdrawal of life support and/or shift to palliation as
the goal of care - Inability to perform adequate electrical impedance
tomography (EIT) measurements - Contra-indications for nasogastric tube or
inability to perform adequate transpulmonary pressure measurements
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method