Resistente HYpertensie: MEten voor Resultaat op Controle Tensie
Recruiting
- Conditions
- Resistant hypertension, therapieresistente hypertensie
- Registration Number
- NL-OMON26643
- Lead Sponsor
- Erasmus Medical Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 310
Inclusion Criteria
Resistant hypertension: office blood pressure > 140/90 mmHg and 24h ABPM (ambulatory blood pressure measurement) daytime blood pressure > 135/85 mmHg despite a medication regimen of antihypertensive drugs from at least three classes including a diuretic.
- Use of at least two drugs for which DBS-analysis is available (enalapril, perindopril, losartan, valsartan, hydrochlorothiazide, spironolactone, amlodipine and nifedipine.
Exclusion Criteria
- Not providing informed consent or not capable of giving informed consent
- Kidney transplantation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Determine whether measuring drug levels combined with personalized feedback leads to a decrease in resistant hypertension after 12 months of follow-up.
- Secondary Outcome Measures
Name Time Method - determine percentage of assumed resistant hypertension at baseline due to non-adherence<br /><br>- Determine the percentage of patients with partial or non-adherence at baseline who are adherent after 12 months of follow-up<br /><br>- Determine whether the number of required antihypertensive drugs is lower in patients who receive feedback on drug levels than in patients who do not. <br /><br>- cost-utility of the intervention versus usual care in resistant hypertention<br /><br>- The number of patients fulfilling the definition of resistant hypertension after 3 and 6 months