Resistant HYpertension: MEasure to ReaCh Targets

Recruiting

• Conditions: high blood pressure; Hypertension; 10057166

• Registration Number: NL-OMON50303
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 392

Inclusion Criteria

* Resistant hypertension: office blood pressure > 140 AND/OR 90 mmHg and 24h
ABPM (ambulatory blood pressure measurement) daytime blood pressure >135 AND/OR
85 mmHg despite a medication regimen of antihypertensive drugs from at least
three classes including a diuretic or the use of at least four antihypertensive
drugs from different classes
* Secondary forms of hypertension have been excluded according to local
guidelines or a secondary form of hypertension has been established or is
likely but chosen treatment is drug therapy (for instance primary
hyperaldosteronism, renovascular hypertension)
* Use of at least two drugs for which DBS-analysis is available (angiotensin
converting enzyme inhibitors: enalapril and perindopril; angiotensin II
receptor blockers: candesartan, irbesartan, losartan, telmisartan, valsartan;
diuretics: bumetanide, chlorthalidone, hydrochlorothiazide and spironolactone;
calcium channel blockers: amlodipine, barnidipine, lercanidipine, and
nifedipine; beta blocker: metoprolol; alpha blocker: doxazosine).
* Age * 18 years
* Providing informed consent after reading patient information

Exclusion Criteria

* Not providing informed consent or not capable of giving informed consent
* End-stage renal disease (eGFR<15 ml/min)
* Insufficient understanding of Dutch or Turkish language

Study & Design

• Study Type: Interventional
• Study Design: Not specified