Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Regulation of Psychophysiological Functions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stress
- Sponsor
- University Hospital, Basel, Switzerland
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Blood oxygenation level dependent signal of the target brain region of interest
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to determine the potential efficacy of real-time functional magnetic resonance imaging neurofeedback (RT- functional magnetic resonance imaging (fMRI) -NF) in regulating brain activity and psychophysiological functions.
Detailed Description
The overall goal of the outlined study is to establish a real-time functional magnetic resonance imaging neurofeedback (RT-fMRI-NF) protocol aiming at modulating brain activity and psychophysiological functions. About two weeks after the initial training session it will be estimated how stable training effects have been. The two weeks in between, subjects will receive ambulatory training of the strategies via a smartphone-based application.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Sufficient spoken and written knowledge of English
- •Right-handedness
- •Access to smartphone
- •Availability to participate in the study
Exclusion Criteria
- •Color blindness
- •Presence of cardiovascular disease
- •Medication intake affecting cardiovascular function
- •Medical MRI contraindication
Outcomes
Primary Outcomes
Blood oxygenation level dependent signal of the target brain region of interest
Time Frame: study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year)
blood oxygenation level dependent (BOLD) signal assessed via functional magnetic resonance imaging, expressed in relative BOLD signal intensity
Blood pressure
Time Frame: study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year)
assessed via oscillometry, expressed in mmHg
Secondary Outcomes
- Feedback on adverse events during the scanner and ambulatory training(study day 1; study day 2 (2 weeks later); anticipated: follow-up (up to 1 year))