DRKS00031914招募中不适用
nderstanding and monitoring renal microvascular remodeling in CKD by super-resolution ultrasound
Klinik für Nieren- und Hochdruckkrankheiten, Rheumatologische und Immunologische Erkrankungen, Uniklinik RWTH Aachen0 个研究点目标入组 50 人开始时间: 2023年5月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •1. Patients after kidney transplantation with a GFR = 20 ml/min (study part A)
- •2. Patients with chronic renal insufficiency with a GFR = 20ml/min (study part B).
- •3. Written informed consent
- •4. Persons who are legally competent and mentally capable of following the instructions of the study personnel.
排除标准
- •1. Minority (Underage)
- •2. Hypersensitivity/allergy to ultrasound contrast agents or their components sulfur hexafluoride, macrogol 4000, colfosceril stearate, 1-(1,2-dipalmitoyl-3-sn-phosphatidyl)glycerol sodium salt palmitic acid
- •3. Right-to-left shunt
- •4. Signs of cardiovascular instability, such as recent acute coronary syndrome or clinically unstable ischemic heart disease, evolving or ongoing acute myocardial infarction, typical angina pectoris at rest within the past 7 days, recent coronary interventions (e.g., cardiac catheterization with stent placement), acute heart failure, class III/IV heart failure, severe cardiac arrhythmias.
- •5. Acute endocarditis
- •6. Artificial heart valves
- •7. Acute systemic inflammation and/or sepsis
- •8. Hypercoagulable state and/or recent thromboembolism
- •9. End-stage kidney or liver disease
- •10. Severe pulmonary hypertension (pulmonary arterial pressure > 90 mmHg)
- •11. Uncontrolled systemic hypertension
- •12. Acute respiratory distress syndrome
- •13. Clinically significant lung disease, including severe chronic obstructive pulmonary disease
- •14. Pregnancy
- •15. Individuals detained in an institution by government or court order
- •16. Individuals who have a dependent or employment relationship with the sponsor or investigator
- •17. Alcohol and substance abuse
- •18. Expected non-compliance
研究者
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