nderstanding and monitoring renal microvascular remodeling in CKD by super-resolution ultrasound
- Conditions
- N18Chronic kidney disease
- Registration Number
- DRKS00034268
- Lead Sponsor
- niklinik RWTH Aachen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
1. Patients after kidney transplantation with GFR = 20 ml/min (Study part A)
2. Patients with CKD with GFR = 20 ml/min (Study part B)
3. Written consent
4. Patients who are contractually capable and able to follow the requests of the study staff
1. minors
2. allergy against ultrasound contrast agent or components sulfur hexafluoride, macrogol 4000, Colfoscerilstearat, 1-(1,2-Dipalmitoyl-3-sn-phosphatidyl)glycerol-Natriumsalt Palmitic acid
3. Left-right -shunt
4. signs of cardiovascular instability such as acute coronary syndrome, clinically instable ischemic heart disease, acute myocardial infarction, angina pectoris within 7 days prior, recent coronary intervention (PTA with or without stent), acute cardiac failure, cardiac insufficiency NYHA III or IV, severe arrhythmias
5. acute endocarditis
6. artificial heart valves
7. acute systemic inflammation and/or sepsis
8. coagulopathy or recent thromboembolic event
9. liver or kidney disease in end stage
10. severe pulmonary hypertension (pA pressure >90mmHg)
11. uncontrolled systemic hypertension
12. acute respiratory distress syndrome
13. clinically significant pulmonary disease including severe COPD
14. pregnancy
15. persons under official directive (prisoners, e.g.)
16. persons who are working for the sponsor or are dependent of the sponsor
17. alcohol or drug misuse
18. expected non-compliance
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method