Detection of retinal and peripheral microvascular abnormalities in ankylosing spondylitis patients * a proof of concept study.
Completed
- Conditions
- Bechterew's diseasemicrovascular disease100110821000381610003216
- Registration Number
- NL-OMON46051
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 55
Inclusion Criteria
* Age 50-75 years
* Diagnosis of AS according to the 1984 modified New York Criteria
Exclusion Criteria
* Diagnosis of diabetes mellitus.
* History of an ischaemic stroke or cerebral haemorrhage.
* History or evidence of glaucoma, significant cataract or cataract surgery in the 6 months prior.
* Active anterior uveitis during the study visit
* Rheumatic disease other than related to AS (so: psoriatic arthritis and Inflammatory Bowel Disease are allowed)
* Current use of systemic and/or ocular corticosteroids
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are the aspects of the retinal arterioles and<br /><br>venules, identified with SIVA (Singapore I Vessel Assessment) software of the<br /><br>fundus photos and the retinal thickness and vascular density on (angio) ocular<br /><br>coherence tomography. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary parameter is the reactive hyperaemia index (RHI), measured with<br /><br>EndoPAT (and calculated automatically by its software). Furthermore, patient<br /><br>characteristics, AS disease characteristics, disease activity parameters,<br /><br>medication, cardiovascular risk factors and diseases, physicical exercise,<br /><br>profession (white or blue collar), laboratory measurements (CRP, ESR, lipid<br /><br>profile) and anthropometric measurements (blood pressure, BMI, arthritis,<br /><br>enthesitis) will be collected.</p><br>