Association Between Early Extubation and Postoperative Complications After Liver Transplantation: A Retrospective Propensity Score-matched Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 438
- 试验地点
- 1
- 主要终点
- The incidence of a composite of 30-day all-cause mortality, AKI and moderate to severe pulmonary complications.
研究概览
简要总结
This is a retrospective cohort study. Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study and divided into two groups. Operating room extubation group: early extubation in the operating room immediately following liver transplantation. Intensive care unit (ICU) extubation group: delay extubation in the ICU following liver transplantation. The primary objectives were to compare the incidence of composite outcome between the two groups. secondary objectives were to compare outcomes such as length of stay, hospital length of stay, and total cost between the two groups.
详细描述
Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study. Inclusion criteria: (1) adult patients (age ≥ 18 years), (2) undergoing liver transplantation. Exclusion criteria were the following: (1) re-transplantation; (2) multi-visceral transplantation; (3) intraoperative death; (4) severe encephalopathy (West Haven criteria III or IV); (5) those who had preoperative mechanical ventilation; (6) incomplete clinical data. The primary objectives was a composite of 30-day all-cause mortality, in-hospital AKI, or in-hospital moderate to severe pulmonary complications. Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery. The secondary objectives included in-hospital moderate to severe infectious complications, unplanned reintubation rates, ICU and postoperative hospital lengths of stay, and total hospital cost.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (age ≥ 18 years)
- •Undergoing liver transplantation
排除标准
- •Re-transplantation
- •Multi-organ transplants
- •Intra-operative deaths
- •severe encephalopathy (West Haven criteria III or IV)
- •patients who had preoperative mechanical ventilation or fulminant hepatic failure
- •Incomplete clinical data
结局指标
主要结局
The incidence of a composite of 30-day all-cause mortality, AKI and moderate to severe pulmonary complications.
时间窗: through study completion, an average of 1 year
Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery
次要结局
- The incidence of moderate to severe infectious complications(30 days)
- The length of ICU stay(through study completion, an average of 1 year)
- The incidence of re-intubation.(30 days)
- The length of hospital stay(through study completion, an average of 1 year)
- The total hospital cost(30 days)
研究者
Chunling Jiang
Professor
West China Hospital