Evaluation of efficacy of Riluzole in the treatment of Methamphetamine

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 40

Inclusion Criteria

Dependence to Methamphetamine according to DSM-IV criteria, consent and commitment for treatment cooperation, age above 18 and under 65. Exclusion criteria: Past history of sensitivity to Riluzole? past history of structural or functional liver disease or abnormal liver function tests (Ast, Alt). 5fold increase in liver enzymes test (Ast,Alt) or jaundice? abnormal renal function tests at the beginning of the study? interstitial lung disease or hypersensitive pneumonitis? neutropenia? pregnancy or lactation? developing psychiatric disorders or previous neurologic disorders like psychosis? bipolar disorders? major depression, tic disorders? Tourette's syndrome or any psychiatric disorders that need medical therapy or makes dependency to addiction therapy complicated; developing significant clinical cardiovascular disorders? physical exam or electrocardiography? family history of disability or premature cardiovascular mortality in first degree relatives? past history of severe untreated physical disabilities? abnormal vital signs.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Adherence to treatment. Timepoint: Once a week. Method of measurement: Refer the patient to receive the drug(questionnaire).;The proportion of negative urine test results. Timepoint: Once a week. Method of measurement: urine test.;Depression. Timepoint: Beginning and end of treatment. Method of measurement: Hamilton Depression Rating Scale.;Craving for methamphetamine. Timepoint: Monthly. Method of measurement: questionnaire.;Addiction Severity. Timepoint: Monthly. Method of measurement: ASI: Addiction Severity Index.;Methamphetamine dependence. Timepoint: Monthly. Method of measurement: ASI: Addiction Severity Index Questionnaire.

Secondary Outcome Measures

Name	Time	Method
Clinical examination of the pulse, and blood pressure. Timepoint: On admission and then weekly. Method of measurement: Clinical examination.;Riluzole side effects. Timepoint: Weekly. Method of measurement: questionnaire.