etrozole effect in IVF cycles

Phase 3

Conditions: Polycystic ovarian syndrome.
Polycystic ovarian syndrome
E28.2

Registration Number: IRCT20150105020558N3

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 510

Inclusion Criteria

The patients with impression of polycystic ovarian syndrome according to Rotterdam consensus as fulfilling at least two of the three criteria: 1- oligo/anovulation; 2- clinical or biochemical signs of hyperandrogenism; and 3- polycystic ovarian morphology on ultrasound
Female age: 18 - 40 years old
The candidate of frozen embryo transfer

Exclusion Criteria

The other causes of hyperandrogenism and ovarian dysfunction
Basal FSH level >10 IU/L
History of recurrent miscarriage
History of congenital or acquired uterine malformations
History of male factor infertility

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ive Birth Rate. Timepoint: After pregnancy termination. Method of measurement: The number of deliveries that resulted in a live born neonate, expressed per 100 embryo transfers.

Secondary Outcome Measures

Name	Time	Method
Clinical Pregnancy Rate. Timepoint: 4 to 6 weeks after frozen embryo transfer. Method of measurement: A visible gestational sac by transvaginal ultrasound.;Ongoing Pregnancy Rate. Timepoint: After 20th weeks of pregnancy. Method of measurement: The number of fetuses with heart activity beyond 20 weeks of gestation.;Cycle cancellation rate. Timepoint: from 15th until 21th days of cycle. Method of measurement: The number of cancelled cycles.;Endometrial thickness. Timepoint: On the day of HCG injection. Method of measurement: The measuring of endometrial thickness by transvaginal ultrasound.;Abortion rate. Timepoint: From 5th until 24th gestational weeks. Method of measurement: The detection of lack or loss of fetal heart activity by ultrasound.;Premature delivery rate. Timepoint: From 25th until 36th gestational weeks. Method of measurement: The delivery of fetus(es).