Comparison of treatment outcomes between letrozole with Gonadotropins in Polycystic Ovarian Syndrome patients
Phase 2
- Conditions
- Disorders of other endocrine glands.Polycystic ovarian syndrome
- Registration Number
- IRCT201106271233N2
- Lead Sponsor
- Vice Chancellor for research-Guilan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 130
Inclusion Criteria
having PCOS according to Rotterdam criteria and, infertility for one year, age 20-39 years old
Exclusion criteria: tubal obstruction, infertility with male factor, hypersensitivity to Clomiphene Citrate or letrozole, presence of diabetes, thyroid or kidney disease, ovarian drilling, ovarian cyst on day 3 of menstrual cycle
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endometrial thickness. Timepoint: Every 2-3 days. Method of measurement: Transvaginal ultrasonography.
- Secondary Outcome Measures
Name Time Method Follicles greater than 16mm. Timepoint: Every 2-3 days. Method of measurement: Transvaginal sonography.;Clinical pregnancy. Timepoint: 14days after IUI. Method of measurement: Ultrasonography two weeks after positive BHCG for finding gestetaional sac.;Chemical pregnancy. Timepoint: 14days after IUI. Method of measurement: bHCG measurment.;E2 level. Timepoint: Once in a cycle. Method of measurement: On the day of HCG injection by blood sampling.;Cancellation rate. Timepoint: Every 2-3 days. Method of measurement: Transvaginal sonograhy.;The number of Gonadotropines used. Timepoint: at the end of the cycle. Method of measurement: Number of Ampoules.