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Clinical Trials/NCT03164200
NCT03164200CompletedNot Applicable

An Egg Based Breakfast Maintains Flexibility in Older Adults

University of Alabama at Birmingham0 sites33 target enrollmentStarted: December 14, 2011Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
33
Primary Endpoint
Respiratory quotient (RQ, a measure of substrate oxidation)

Study Overview

Brief Summary

Aging is associated with an increased risk for metabolic diseases, such as type 2 diabetes and cardiovascular disease. There is reason to believe that the time of day when specific food groups are eaten affects this risk. The investigators propose that eating foods made up of fat and protein (such as eggs) in the morning for breakfast, rather than foods made up of carbohydrates (such as white-bread toast or sugary cereal) may promote a healthier metabolism. This is because the body is designed to burn fat during times of fasting, such as overnight, during sleep. Thus, the body is not prepared to burn sugar early in the morning, when most people eat breakfast. Studies with mice have shown that a sugary breakfast meal inhibits the ability of the body to burn fat for the entire day. In contrast, a breakfast meal with more fat enabled the animals to burn fat as well as other fuels throughout the day. The ability to burn fat is thought to minimize risk for obesity, as well as related diseases such as type 2 diabetes and heart disease. The purpose of this study is to determine if, in older adult humans, consumption of a lower-carbohydrate breakfast meal (relative to a higher-carbohydrate meal) is associated with a healthier metabolism.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Other
Masking
None

Masking Description

Patients were randomized to either a egg breakfast or a carbohydrate breakfast

Eligibility Criteria

Ages
55 Years to 75 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • • Age 55-75
  • Body mass index 24-29 kg/m2

Exclusion Criteria

  • • Current practice of greater than 2h/wk of moderate intentional exercise
  • Uncontrolled diabetes
  • Unwillingness to eat study diets
  • Use of any medication known to affect metabolism
  • History of eating disorder
  • Difficulty chewing and swallowing solid food
  • Digestive diseases
  • Cognitive impairment
  • Depression
  • Recent weight change (+/- 10 lbs. in the last 12 mo.)
  • Poorly controlled blood pressure (SBP > 159 or DBP >95 mm Hg)
  • History of non-skin cancer in the last 5 y
  • Cardiovascular disease event in the past 6 mo.
  • Severe pulmonary disease
  • Renal failure
  • Major liver dysfunction (elevation of liver transaminases >3x normal in past 2 y; current/recent smoker (within 6 mo.)
  • Use of estrogen or testosterone replacement therapy
  • Current use of oral corticosteroids >5 days/month on average
  • Current use of medications for treatment of psychosis or manic-depressive illness
  • Use of weight loss medications in the previous 3 months
  • Unable to adhere to diet recommendations

Outcomes

Primary Outcomes

Respiratory quotient (RQ, a measure of substrate oxidation)

Time Frame: 4 weeks

24 hour respiratory quotient will be measured using whole-room indirect calorimetry

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Barbara Gower

Professor

University of Alabama at Birmingham

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