To compare two drugs, dexamethasone and granisetron in their ability to prevent vomiting after surgery in women
- Conditions
- Postoperative nausea and vomiting in female patients undergoing elective laparoscopic surgery
- Registration Number
- CTRI/2017/11/010507
- Brief Summary
This was a prospective, randomized study to compare the antiemetic efficacy of dexamethasone 8 mg given intravenuously with granisetron 3 mg intravenously for elective laparoscopic surgery in women. Our hypothesis was that dexamethasone given intravenously prior to induction of anesthesia is a better antiemetic than granisetron.
There was no statistically significant difference in the PONV intensity scores between the two groups at all time points of assessment (p>0.05 at all times assessed). There was no statistically significant difference in the consumption of rescue antiemetic metoclopramide between the two groups (p=0.741)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 50
ASA I and II Female patients undergoing elective laparoscopic procedures Non pregnant.
Emergency surgery ASA III and above Patients with preoperative vomiting BMI greater than 30 History of steroid use Patients with contraindication to study drugs Pregnancy and lactation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PONV intensity score 6h, 12h, 18h, 24h, 72h after surgery
- Secondary Outcome Measures
Name Time Method Time of first rescue antiemetic administration, total postoperative metoclopramide consumption 24h, 72h after surgery
Trial Locations
- Locations (1)
Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University
🇮🇳Chennai, TAMIL NADU, India
Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University🇮🇳Chennai, TAMIL NADU, IndiaPrasanth GanesanPrincipal investigator04423860830ganesanprashanth@gmail.com