Prospective Evaluation of Disparities in Provision of Allogeneic Transplantation

Recruiting

• Conditions: Allogeneic Transplantation
• Interventions: Behavioral: Patient Ancestry Questionnaires

• Registration Number: NCT06450353
• Lead Sponsor: M.D. Anderson Cancer Center

Brief Summary

To look at the effect of a recipient's ancestry and socio-economic status on their choice of bone marrow transplantation donor cells and their chance of receiving genetically similar (allogeneic) bone marrow cells versus cells that are not genetically similar (allograft).

Detailed Description

Primary Objectives To prospectively evaluate graft options and choice of donor by patient ancestry and SES for allograft candidates at MDACC.

Secondary Objectives

* To prospectively evaluate time to transplant for allograft candidates at MDACC.

* To evaluate treatment-related mortality for allograft candidates at MDACC.

* To assess overall survival for allograft candidates at MDACC.

* To prospectively evaluate receipt of preferred unrelated donor for allograft recipients at MDACC.

* To evaluate receipt of an optimal graft for allograft recipients at MDACC.

Study Timeline

• Study Start: 2024-05-31
• Study First Submitted: 2024-05-31
• Study First Submitted QC: 2024-06-04
• Study First Posted: 2024-06-10
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-08
• Last Update Posted: 2025-01-10
• Primary Completion: 2027-06-01
• Study Completion: 2029-06-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

1. ≥ 18 years of age.
2. Candidate for allogeneic transplantation

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Exclusion Criteria

1. Allogeneic stem cell transplantation not medically indicated.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Prospective evaluation	Patient Ancestry Questionnaires	Participants are expected to be in this research study for up to 2 years after the participants bone marrow transplantation. However, your active participation will only last 1 day, when you sign the consent form and complete a questionnaire about your demographic information and ancestry (family ethnicity). For the rest of the study, information about the participants medical history, choice of bone marrow donor, and health outcomes will be collected from your medical record.

Primary Outcome Measures

Name	Time	Method
Patient Ancestry Questionnaire	Through study completion; an average of 1 year.

Trial Locations

Locations (1)

MD Anderson Cancer Center; 🇺🇸 Houston, Texas, United States