NCT01503944已完成1 期
Detection of Striatal Dopaminergic Degeneration and Neocortical Amyloid Pathology in Patients With Dementia With Lewy Bodies, Alzheimer's Disease, Parkinson's Disease, and Healthy Elderly Volunteers
Avid Radiopharmaceuticals1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2010年3月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- 18F-AV-133 striatal to occipital standard uptake value ratio
研究概览
简要总结
The purpose of this study is to evaluate the ability to identify individuals with dopaminergic degeneration in group of patients with a clinical diagnosis of either dementia with Lewy bodies (DLB) or idiopathic Parkinson's disease and to differentiate them from Alzheimer's disease (AD) and control subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Have a history or current diagnosis of other neurologic disease
- •Have evidence of clinically significant cerebrovascular disease
- •Have evidence from MRI or other biomarker studies that suggests the presence of a CNS pathology other than that associated with the study diseases
研究组 & 干预措施
Dementia with Lewy Bodies
Other
干预措施: 18F-AV-133 (Drug)
Dementia with Lewy Bodies
Other
干预措施: 18F-AV-45 (Drug)
Parkinson's disease
Other
干预措施: 18F-AV-133 (Drug)
Parkinson's disease
Other
干预措施: 18F-AV-45 (Drug)
Healthy Elderly Volunteers
Other
干预措施: 18F-AV-133 (Drug)
Healthy Elderly Volunteers
Other
干预措施: 18F-AV-45 (Drug)
Alzheimer's Disease
Other
干预措施: 18F-AV-133 (Drug)
Alzheimer's Disease
Other
干预措施: 18F-AV-45 (Drug)
结局指标
主要结局
18F-AV-133 striatal to occipital standard uptake value ratio
时间窗: Four Weeks
The ratio of tracer activity in striatal target areas of interest relative to the occipital cortex reference region
次要结局
- 18F-AV-45 cortical to cerebellar standard uptake value ratio(Four Weeks)
研究者
研究点 (1)
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