The Effect of Paricalcitol on Creatinine Filtration, Secretion and Glomerular Filtration Rate
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- 24-hour Urine Creatinine Excretion Rate
研究概览
简要总结
The purpose of this study is to study the effects of Paricalcitol (Zemplar) on kidney functioning. The investigators hypothesize that the increase in serum creatinine observed in recent paricalcitol trials is a function of reduced creatinine secretion and not an actual reduction in kidney function. 16 patients will have kidney function measured via iothalamate clearance at baseline, after 7 days of paricalcitol treatment and after 7 days of being washed off the paricalcitol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Stage 3 or 4 CKD
- •Ability to give informed consent
排除标准
- •Serum Calcium > 10 g/dL
- •Serum Phosphorous > 6 g/dL
- •On > 400 units/d Vitamin D therapy
- •Receiving cimetidine, triamterene, or trimethoprim, drugs that block creatinine secretion
- •On vitamin D receptor activators (paricalcitol, calcitriol or Zemplar)
- •Allergic to radiocontrast dye
研究组 & 干预措施
Paricalcitol
After baseline measurements are complete, pt will receive 2 mcg Paricalcitol (Zemplar) for 7 consecutive days. After this, Kidney function will again be measured. The pt will then be washed off the paricalcitol for 7 days then kidney function will be measured for the last time.
干预措施: Paricalcitol (Drug)
结局指标
主要结局
24-hour Urine Creatinine Excretion Rate
时间窗: 1 Week
We expect the 24 hour urine creatinine excretion rate to show no differences between groups.
次要结局
- Creatinine Clearance(1 Week)
- Serum Creatinine(1 Week)