Older HIV-infected Adults and Drug Interactions: French Cross-sectional Study

Completed

• Conditions: HIV Infections

• Registration Number: NCT03416881
• Lead Sponsor: University Hospital, Caen

Brief Summary

Drug interactions between antiretroviral drugs and concomitants drugs and between antiretroviral need to be studied HIV-population is ageing. The referential of interactions is the Liverpool base.

Detailed Description

Filters in the French social security system database, 2016 :

* Code of Pathology "Human Immunodeficiency Virus (HIV) infection" Age ≥ 65 years

* Treatment with an antiretroviral between January 1, 2016 and December 31, 2016

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2016-12-31
• Study Completion: 2016-12-31
• Status Verified: 2017-11
• Study First Submitted: 2017-11-09
• Study First Submitted QC: 2018-01-30
• Last Update Submitted: 2018-01-30
• Study First Posted: 2018-01-31
• Last Update Posted: 2018-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13225

Inclusion Criteria

• Men and women over than 65 years with an HIV infection and insured at the French Primary Health Insurance fund

No exclusion Criteria

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
frequency of major drug-drug interactions	between Jan, 1st 2016 and Dec, 31st 2016	MDDI between 2 drugs (ARV/ARV or ARV/non-ARV) delivered during the same period yielding to a "Do Not Coadminister" statement, according to the University of Liverpool website (www.hiv-druginteractions.org/checker).

Secondary Outcome Measures

Name	Time	Method
costs associated with major drug-drug interactions	during 2016	The costs were defined as all reimbursed healthcare acts recorded in the SNIIRAM