Cryotechnique as a Diagnostic and Therapeutic Tool of Endobronchial Tumors: A Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 3
- 主要终点
- Diagnostic yield
研究概览
简要总结
This study was to assess the diagnostic yield and the safety of bronchoscopic cryotechniques in the management of endobronchial tumors.
详细描述
Novel flexible cryoprobes were introduced for tissue sampling during bronchoscopy. Employing this approach, the sample is collected when frozen, with the tissue attached to the frozen end of the probe. This approach enables the retrieval of larger tissue samples from endobronchial lesionsEndobronchial cryotherapy is employed to treat individuals with obstructive central bronchial lung cancers. It has been demonstrated to effectively recanalize obstructed respiratory passages, alleviate symptoms, and improve the quality of life for patients in advanced stagesThis study aimed to assess the effectiveness and safety of using bronchoscopic cryotechniques for diagnosing and treating endobronchial malignancies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with radiologically suspected endobronchial masses
排除标准
- •Patients with contraindications to bronchoscopy.
- •uncorrected coagulopathy (if the international normalized ratio (INR) is more than 1.5).
- •severe refractory hypoxemia (even after administering the highest possible dose of oxygen, the partial pressure of oxygen ("PaO2") stays below 70 mm Hg.
- •hypoventilation with hypercapnia (type 2 respiratory failure).
- •severe pulmonary hypertension > 55 mmHg by echocardiography.
- •hemodynamic instability.
结局指标
主要结局
Diagnostic yield
时间窗: within 10 days
The recording of histopathological diagnosis as revealed by cryobiopsy
Recanalization Success
时间窗: one day following the procedure
The measurement of degree of airway recanalization through bronchoscopic evaluation
次要结局
- Degree of dyspnea improvement after the procedure(2 weeks after the procedure)
研究者
Hend Mohammed Abdelraheem Esmaeel
Associate professor
Sohag University