A randomized, double-blind study comparing the effectiveness of inhaled dexmedetomidine versus lidocaine in minimizing coughing and discomfort during extubation (breathing tube removal) following general anesthesia for surgery.

Not yet recruiting

• Conditions: PATIENTS COMING FOR SURGERIES UNDER GENERAL ANAESTHESIA

• Registration Number: CTRI/2025/03/082972
• Lead Sponsor: NIZAMS INSTITUTE OF MEDICAL SCIENCES

Brief Summary

This study is a randomised double blinded controlled study sone to assess to compare the effects of in-line nebulisation with dexmedetomidine vs 2% lidocaine prior to extubation on extubation response in patients undergoing surgery under general anaesthesia. The primary objective is to assess and compare cough response in different groups during extubation and the secondary outcomes are a) To assess and compare the hemodynamic changes during extubation, b) To assess emergence agitation c) To assess any complications, post extubation like stridor due to laryngospasm or any other cause, vomiting, wheeze, desaturation, pulmonary edema. d) Duration of recovery - the time between the point where sevoflurane is cut off and the point where extubation is done.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-03-25
• Last Update Posted: 2025-10-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Written and valid consent ASA I and II Age 18 to 60 years Patients undergoing surgery under General Anaesthesia Duration less than 3 hours.

Exclusion Criteria

Patient refusal Chronic smokers more than 20 pack years Patients with compromised cardiopulmonary respiratory status requiring special anaesthetic plan Head and neck surgery Any known allergy to the study drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess and compare cough response in different groups during extubation.	T0 | Point at which sevoflurane is cut off | T1 | Point where reversal agent is given | T2 | 2 mins after administration of reversal | TE | Point of extubation | T3 | 2 mins after extubation | T4 | 5 mins after extubation | T5 | 10 mins after extubation

Secondary Outcome Measures

Name	Time	Method
To assess & compare the hemodynamic changes during extubation	Point at which sevoflurane is cut off
To assess any complications, post extubation like stridor due to laryngospasm or any other cause, vomiting, wheeze, desaturation, pulmonary edema	Point at which sevoflurane is cut off
Duration of recovery - the time between the point where sevoflurane is cut off & the point where extubation is done	Point at which sevoflurane is cut off
To assess emergence agitation	Point at which sevoflurane is cut off

Trial Locations

Locations (1)

NIZAMS INSTITUTE OF MEDICAL SCIENCES; 🇮🇳 Hyderabad, TELANGANA, India

NIZAMS INSTITUTE OF MEDICAL SCIENCES

🇮🇳Hyderabad, TELANGANA, India

DR MADHU PRIYA V

Principal investigator

8056013924

madhuvenkat96@gmail.com