Prospective, monocentric clinical study about the effect of a novel technique for mucus mobilization on lung function, mucus viscosity and diaphragmatic mobility in cystic fibrosis patients
Not Applicable
- Conditions
- E84.0Cystic fibrosis with pulmonary manifestations
- Registration Number
- DRKS00024819
- Lead Sponsor
- lm University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 21
Inclusion Criteria
diagnosed cystic fibrosis
Exclusion Criteria
- acute infection
- reduced general condition
- massive hemoptysis within the last 4 weeks
- pneumothorax within the last 6 weeks
- uncontrolled asthmatic symptoms
- unstable cardiovascular disease
- unstable pulmonary situation with dyspnea
- pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method lung function parameters (FEV1, MEF25, MEF50, MEF75), measured by spirometry<br>
- Secondary Outcome Measures
Name Time Method 1. Diaphragmatic mobility before and after the intervention; sonographic measurement of the diaphragmatic excursion and speed of the diaphragmatic movement of in- and expiration<br>2. Viscosity and DNA-concentration of the expectorated mucus before and after the intervention; measurement via FRAP (fluorescence recovery after Photobleaching) and dye based determination of DNA-concentration