Prospective, randomized, monocentric study for the determination of device-related dead spaces in the MIRUS-System under controlled ventilation under general anesthesia

Not Applicable

• Conditions: J80; J44; General anaesthesia for orthopaedic surgery; Other chronic obstructive pulmonary disease; Adult respiratory distress syndrome

• Registration Number: DRKS00021648
• Lead Sponsor: Katholisches Klinikum gGmbH, Klinik für Anästhesiologie und operative Intensivmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-12
• Study Completion: 2020-12-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All patients who would like to receive general anaesthesia for orthopaedic surgery at the Catholic Hospital Bochum
- ASA 1-3

ASA
The Classification of the American Society of Anesthesiologists (ASA Classification I- IV) is a widely applied categorization of the preoperative status of patients. It has a good predictive value regarding perioperative morbidity and mortality.

Exclusion Criteria

- lack of clarification or consent
- pregnancy
- simultaneous participation in another study
- ASA IV or higher
- severe lung disease
- intolerance to sevoflurane (e.g. malignant hyperthermia or muscle disease) or piritramide

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- end expiratory CO2 (et CO2)<br>- respiratory minute volume (AMV)

Secondary Outcome Measures

Name	Time	Method
- total dead volume (Vds in ml)<br>- alveolar ventilation (VTalv)<br>= Vds minus the aparative dead space percentage,<br>- Dead space quotients = dead space volume / exhaled breath volume (Vds/VTE)<br>- breathing rate (AF), ventilation pressures, lung compliance, resistance, breathing work (WOB)