Comparison of Propofol, Etomidate and a combination of both on the hemodynamic response

Completed

• Conditions: Calculus of gallbladder without cholecystitis, (2) ICD-10 Condition: N200||Calculus of kidney, (3) ICD-10 Condition: K469||Unspecified abdominal hernia without obstruction or gangrene, (4) ICD-10 Condition: K37||Unspecified appendicitis, (5) ICD-10 Condition: S529||Unspecified fracture of forearm, (6) ICD-10 Condition: H729||Unspecified perforation of tympanic membrane,

• Registration Number: CTRI/2020/11/029445
• Lead Sponsor: Vidarshna V

Brief Summary

Comparative evaluation of Propofol, Etomidate and a combination of Propofol and Etomidate on the hemodynamic response to induction and endotracheal intubation: a prospective randomized double blinded study.

We are trying to prove that a combination of Propofol and Etomidate provides good intubating conditions ( effect of propofol - suppressing laryngeal reflexes) while maintaining stable hemodynamics ( effect of Etomidate )

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-12
• Study Completion: 2021-11-24
• Last Update Posted: 2021-12-18

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

• ASAI • Surgery under General Anaesthesia • Age 18-50 yrs • Male and Female patients.

Exclusion Criteria

• Patient refusal • ASA II or higher • Emergency surgery requiring Rapid Sequence Induction and Intubation • Allergy to Propofol / Etomidate • Anticipated Difficult Airway.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
hemodynamic response to induction and endotracheal intubation	Hemodynamic parameters (Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure) will be recorded at pre-induction(baseline),1, 2, and 3 minutes after induction and then at 0, 3, 5 and 10 minutes after endotracheal intubation.

Secondary Outcome Measures

Name	Time	Method
Incidence of hypotension	Hemodynamic parameters (Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure) will be recorded at pre-induction(baseline),1, 2, and 3 minutes after induction and then at 0, 3, 5 and 10 minutes after endotracheal intubation.

Trial Locations

Locations (1)

Sri Ramachandra Institute of Higher Education and Research; 🇮🇳 Chennai, TAMIL NADU, India

Sri Ramachandra Institute of Higher Education and Research

🇮🇳Chennai, TAMIL NADU, India

Dr Vidarshna V

Principal investigator

8056021817

vid7209@gmail.com