Connectivity changes as a pathological link between striatal and cortical metabolism in subtypes of patients with Parkinson's disease. A multimodal longitudinal study.
- Conditions
- G20Parkinson disease
- Registration Number
- DRKS00005388
- Lead Sponsor
- niklinik KölnKlinik und Poliklinik für Neurologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 85
Patients with PD: A diagnosis of Parkinson's Disease meeting the British Brain Bank Criterias; Hoehn & Yahr I-II; A tolerable withdraw of 12 hours of non retarded dopaminergic medication or of 72 hours of retarded medication, respectivly; Age 55 - 80 y; Good command of german; Written informed consent
Healthy controls: Age > 55 y; Written informed consent
Patients with PD: Existence of a disease which affect the cognition; Depression (BDI > 20 points); Dementia (PANDA < 14 points), Imcompliance; Containdications for MRI: cardiac pacemaker, artificial cardiac valve, internal metalic objects, pregnancy, during the period of lactation, claustrophobia, adipositas (BMI > 30)
Healthy controls: Neurological diseases; treatment with drugs affecting the CNS, which cannot be withdrawed at least 12 hours before testing; Containdications for MRI: cardiac pacemaker, artificial cardiac valve, internal metalic objects, pregnancy, during the period of lactation, claustrophobia, adipositas (BMI > 30)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification and presentation of genetic and metabolomic changes and significantly changed connectivity in cerebral networks, which differ in between subtypes of parkinsons disease. We compare imaging data ([18F]FDG-PET,[18F]Dopa-PET,rsMRT) and clinical data of patients and healthy controls at baseline and of patients at baseline and 2-year-follow-up.
- Secondary Outcome Measures
Name Time Method