National Collaborative Study of Girls Prenatally Diagnosed With Turner Syndrome Karyotypes
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Seattle Children's Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Number of signs of Turner syndrome
Study Overview
Brief Summary
The goal of this study is to compare the features of Turner syndrome in girls who are diagnosed before birth because of fetal concerns versus those who are diagnosed when their mother has an amniocentesis for another reason.
Detailed Description
This is an observational study which will look at girls who are diagnosed with Turner syndrome before they are born. Girls will be divided into two groups: 1) those diagnosed because of features seen on ultrasound which raised the question of Turner syndrome and 2) those diagnosed incidentally when their mother had an amniocentesis for another reason such as advanced maternal age.
No clinical procedures nor interventions will be done as part of this data collection study which will occur for the first 3 to 6 years of the girl's life. The investigators will be looking to see if girls who are diagnosed incidentally have less features of Turner syndrome than those girls who are diagnosed because of fetal ultrasound.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- — to 3 Months (Child)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Turner syndrome diagnosed prenatally
- •Less than 4 months of age at time of enrollment
Exclusion Criteria
- •Turner syndrome diagnosed postnatally
- •Older than 4 months of age at time of enrollment
Outcomes
Primary Outcomes
Number of signs of Turner syndrome
Time Frame: three to six years
Girls diagnosed with Turner syndrome by fetal ascertainment will have more signs of Turner syndrome than girls diagnosed by maternal ascertainment
Secondary Outcomes
- Growth(three to six years)
Investigators
Patricia Fechner
Associate Professor, Pediatrics
Seattle Children's Hospital