Prevalence of somatic KCNJ5 mutations in patients with aldosterone-producing adenoma in King Chulalongkorn Memorial Hospital

Not Applicable

Completed

• Conditions: Prevalence of somatic KCNJ5 mutations Resolution of hypertension and hypokalemia at one year after surgery Clinical characteristics of patients with and without somatic KCNJ5 mutations; aldosterone- producing adenoma; resolution of hypertension; somatic KCNJ5 mutations; unilateral adrenalectomy

• Registration Number: TCTR20170522002
• Lead Sponsor: Ratchadapiseksompotch Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-12-31
• Study Start: 2017-05-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 131

Inclusion Criteria

Adults aged 18 years old or older
Diagnosed APA according to an Endocrine Society practice guidelines1
Underwent unilateral adrenalectomy in KCMH from 2006-2016
Had adrenal tissues for DNA sequencing

Exclusion Criteria

patients with postoperative persistent hyporeninemic hyperaldosteronism

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence of somatic KCNJ5 mutations in patients with aldosterone-producing adenoma one year genetic study

Secondary Outcome Measures

Name	Time	Method
clinical characteristics of patients with somatic KCNJ5 mutations one year chart review and case record form