Neutrophil, Lymphocyte and Platelet as a Predictor for AKI and Mortality

Completed

• Conditions: Acute Kidney Injury
• Interventions: Procedure: Cardiovascular surgery with cardiopulmonary bypass

• Registration Number: NCT02916043
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

Detailed Description

Acute kidney injury (AKI) after cardiovascular surgery remains a serious complication associated with increased mortality for up to 10 years. The incidence of AKI after cardiovascular surgery is as high as 55% and the incidence of renal replacement therapy (RRT) to be up to 8 %.

Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

Study Timeline

• Study Start: 2016-04
• Status Verified: 2016-09
• Study First Submitted: 2016-09-25
• Study First Submitted QC: 2016-09-25
• Study First Posted: 2016-09-27
• Primary Completion: 2016-11
• Study Completion: 2016-11
• Last Update Submitted: 2016-11-13
• Last Update Posted: 2016-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1099

Inclusion Criteria

• Adult patients who underwent cardiovascular surgeries with cardiopulmonary bypass (CPB), including valve replacement and surgery on the thoracic aorta at the Seoul National University Hospital between 2007 and 2015

Exclusion Criteria

• Missing preoperative serum creatinine (sCr) values
• Missing preoperative platelet, neutrophil and lymphocyte counts
• Patients who underwent preoperative hemodialysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cardiovascular surgery with cardiopulmonary bypass	Cardiovascular surgery with cardiopulmonary bypass	Cardiovascular surgery with cardiopulmonary bypass

Primary Outcome Measures

Name	Time	Method
Acute kidney injury	postoperative day seven	acute kidney injury during postoperative seven days defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria

Secondary Outcome Measures

Name	Time	Method
All-cause mortality	postoperative seven years	all-cause mortality after cardiovascular surgery after postoperative seven years

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of