Hippocampal blood flow and electroconvulsive therapy in depressio
Completed
- Conditions
- DepressionDepressive disorder10027946
- Registration Number
- NL-OMON29749
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
Patients who meet DSM-IV criteria for depressive disorder and meet the Dutch Psychiatric Association criteria for electroconvulsive therapy. Healthy control subjects who do not meet any DSM-IV criteria. Age between 18 and 65.
Exclusion Criteria
Patients who do not meet DSM-IV criteria for depressive disorder. Healthy controls who meet the criteria for a DSM-IV diagnosis. Subjects who have severe cognitive impairments (e.g. vascular or Alzheimers dementia), severe medical conditions (e.g. coronaire heart disease, COPD, diabetes), non removable metal objects. Subjects who are pregnant or lactating.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameter will be changes in hippocampal blood flow as a<br /><br>result of ECT measured in ml/min/100g</p><br>
- Secondary Outcome Measures
Name Time Method <p>Differences in hippocampal bloodflow between depressed patients and healthy<br /><br>controls measured in ml/min/100mg.<br /><br>Changes in depression score before and after ECT treatment as measured by means<br /><br>of the Hamilton depression rating scale.</p><br>