Role of cerebral blood flow pulsatility in hypertension related brain damage
- Conditions
- HypertensionCerebral Small Vessel Disease (cSVD)
- Registration Number
- NL-OMON20070
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 75
Criteria for the hypertensive group without known brain damage:
- Age 40-75 years
- Essential hypertension, defined as an ambulant blood pressure of = 130 over 80 mmHg.
Criteria for the hypertensive group with diagnosed brain damage (Fazekas=2):
- Age 40-75 years
- Essential hypertension, defined as an ambulant blood pressure of = 130 over 80 mmHg.
- Extensive white matter lesions: Fazekas score = 2, indicated on brain MRI.
Criteria for the control (normotensive) group:
- Age 40-75 years
- Normotensive (ambulant blood pressure of < 130 over 80 mmHg).
- White coat hypertension
- Inability to stop antihypertensive medication (since this results in an altered blood pressure, not the original blood pressure before the use of medication.)
- Indication of history-taking, physical examination or routine laboratory tests of secondary hypertension
- Chronic renal insufficiency (eGFR<30 mL/min)
- Diabetes mellitus
- Ischemic or valvular heart disease or electrocardiographic evidence of atrial fibrillation
- Transient ischemic attacks and ischemic or hemorrhagic stroke
- Obstructive sleep apnea syndrome
- Systemic inflammation, such as active rheumatoid arthritis
- Body Mass Index > 32 kg/m²
- Inability to provide informed consent
- Any contraindication for MRI: metallic implants, pacemaker, claustrophobia, pregnancy, tattoos in the head/neck region, permanent make-up.
- Contraindications for the gadolinium-containing contrast agent: allergic reaction, eGFR<30 mL/min
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Cerebral blood flow pulsatility index in the small cerebral vessels measured with 7T MRI in hypertensive patients and healthy controls
- Secondary Outcome Measures
Name Time Method Brain tissue integrity (white matter lesions, brain microbleeds, enlarged perivascular spaces, lacunes, blood-barrier disruption, gray matter neuronal activity, tissue integrity/diffusivity), blood perfusion, cardiovascular properties, and cognitive performance.