Acupuncture for diminished ovarian reserve: a multicenter randomized controlled trial
- Conditions
- Diminished ovarian reserve
- Registration Number
- ITMCTR2200006407
- Lead Sponsor
- Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- Not specified
(1) aged between 20-40;
(2) meet the diagnostic criteria of DOR;
(3) have a need for fertility, and intend to have a spontaneous pregnancy or to use an antagonist regimen to promote ovulation in the next IVF cycle evaluated by a reproductive physician;
(4) volunteer to participate in the trial and sign an informed consent form.
(1) combined with any kind of related diseases that affect conception like congenital developmental abnormalities of reproductive organs, untreated endometrial polyps, untreated uterine infection, etc; (2) combined with polycystic ovarian syndrome (PCOS); (3) combined with untreated hyperprolactinemia, hyperandrogenemia, abnormal thyroid function, chronic adrenal hypofunction, and other metabolic endocrine diseases; (4) combined with severe cardiovascular, cerebrovascular, liver, kidney, malignant tumors, hematopoietic system, and mental diseases; (5) have received acupuncture treatment related to improving fertility in the past three months; (6) expect to receive IVF-ET within 2 months after enrollment.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Antral Follicle Count;
- Secondary Outcome Measures
Name Time Method E2 level on HCG day;Number and rate of 2PN;High-quality embryo rate;Live birth rate;Intima thickness on HCG day;Continuous pregnancy rate;Available embryo rate;Biochemical pregnancy rate;Embryo implantation rate;MII oocytes;SAS score;Level of FSH;Cycle cancellation rate;Level of AMH;Number of follicles = 14mm;Clinical pregnancy rate;Early pregnancy loss rate;