How acupuncture improves ovarian function and pregnancy outcomes in women with diminished ovarian reserve: a clinical and mechanistic study

Not Applicable

• Conditions: Women with infertility due to diminished ovarian reserve including those with or without transferable embryos; Pregnancy and Childbirth

• Registration Number: ISRCTN69623204
• Lead Sponsor: Shenzhen Municipal People's Government

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-01-10
• Last Update Posted: 22 January 2024
• Study Completion: 2026-10-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 164

Inclusion Criteria

1. Women aged 20 to 42 years
2. Conforming to the clinical diagnostic criteria for DOR
3. Voluntary and written informed consent

Exclusion Criteria

1. Male factor infertility characterized by severe oligospermia, asthenospermia, necrospermia, teratospermia, or azoospermia
2. Conditions such as severe hydrosalpinx, significant tubal or pelvic adhesions, and myomas invading the endometrium, which adversely affect the outcome of IVF pregnancies
3. Immune system disorders such as immune nephritis and systemic lupus erythematosus, which may lead to infertility
4. Endocrinopathies such as hyperprolactinemia, hyperandrogenemia, chronic adrenal insufficiency, and marked thyroid dysfunction
5. Infertility attributable to congenital malformations of the reproductive system, chromosomal anomalies, or other genetic etiologies
6. Coexistence of severe cardiovascular, cerebrovascular, hepatic, renal, or hematopoietic disorders, malignant neoplasms, or psychiatric conditions.
7. Contraindications to pregnancy or uterine non-viability for gestation
8. Received DOR-related interventions (ie. drugs, acupuncture, herbs, etc.) within 4 weeks
9. Subjects considered ineligible for trial participation based on researcher evaluation

Study & Design

• Study Type: Interventional
• Study Design: Not specified