Effect of acupuncture on clinical outcomes of patients with repeated implantation failure
- Conditions
- patients with repeated implantation failure
- Registration Number
- ITMCTR2100004345
- Lead Sponsor
- Obstetrics and Gynecology Hospital of Fudan University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
1. Meet any of the following:
1) More than 3 times of embryo transfer failed, and at least 4 high-quality embryos were transferred;
2) Two consecutive embryo transfer failures, and at least 4 high quality embryos were transferred.
2. IVF / ICSI / PGD for embryo transfer;
3. 1-2 high-quality embryos at D3 cleavage stage or blastocysts will be transffered for IVF or ICSI, and only one blastocyst will be transferred from PGD;
4. Aged 20-38 years;
5. Sign informed consent voluntarily.
1. Those who have contraindications to pregnancy or assisted reproductive technology;
2. Chromosomal abnormalities of either spouse (except polymorphism);
3. Abnormal gene diseases via PGD examination;
4. Untreated uterine diseases (uterine malformation, submucous myoma, adenomyosis, endometriosis, etc.) which affect the shape of uterine cavity;
5. AMH < 1.1ng/ml or AFC < 7;
6. The endometrial thickness on the day of transformation/ovulation less than 7 mm;
7. More than 2 times of clinical pregnancy abortion;
8. Patients with serious primary diseases in cardiovascular, liver, kidney, and hematopoietic system, or with mental diseases;
9. Those who have been given treatment (such as acupuncture and Traditional Chinese Medicine) related to regulating menstruation and helping pregnancy in the lateset 3 months.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical pregnancy rate;live birth rate;
- Secondary Outcome Measures
Name Time Method ongoing pregnancy rate;Resistance index of uterine artery;Biochemical pregnancy rate;Early pregnancy loss rate;Embryo implantation rate;Pulsatility index of uterine artery;endometrial and subendometrial blood flow;