Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma

Registration Number
NCT05409066
Lead Sponsor
Genmab
Brief Summary

Follicular Lymphoma (FL) is the second most common B-cell cancer and the most common type of cancer of lymphocytes. Unfortunately, this disease is incurable with conventional treatment and the disease recurs in almost all patients. This study will assess how safe and effective epcoritamab is in combination with lenalidomide and rituximab (R2) in treating adu...

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
500
Inclusion Criteria
  • Eastern Cooperative Oncology Group (ECOG) performance status score 0 to 2.

  • Participant has:

    • Fluorodeoxyglucose-positron emission tomography (FDG-PET) scan demonstrating positive lesion compatible with computed tomography (CT) or magnetic resonance image (MRI)-defined anatomical tumor sites AND
    • >= 1 measurable nodal lesion (long axis > 1.5 cm) or >= 1 measurable extra-nodal lesion (long axis > 1.0 cm) on CT scan or MRI.
  • Histologically confirmed classic follicular lymphoma (FL) [previously Grade 1 to 3a FL] stage II, III, or IV with no evidence of histologic transformation to an aggressive lymphoma and CD20+ disease on most recent representative tumor biopsy based on the pathology report.

  • Relapsed or refractory (R/R) disease to at least one prior systemic regimen that contained an anti-CD20 monoclonal antibody (mAb) in combination with chemotherapy. (Participant who received only prior anti-CD20 mAb monotherapy and/or radiation therapy is not eligible.)

  • Eligible to receive R2 per investigator determination.

  • Estimated Creatinine Clearance (CrCl) >= 50 mL/min.

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Exclusion Criteria
  • Documented refractoriness to lenalidomide.
  • Have lenalidomide exposure within 12 months prior to randomization.
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Lenalidomide and Rituximab (R2)RituximabParticipants will receive lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days).
Epcoritamab Dose A in Combination With R2EpcoritamabParticipants will receive epcoritamab Dose A in combination with lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days).
Epcoritamab Dose A in Combination With R2RituximabParticipants will receive epcoritamab Dose A in combination with lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days).
Epcoritamab Dose B in Combination With R2EpcoritamabParticipants will receive epcoritamab Dose B in combination with lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days). Enrollment is closed for this arm.
Epcoritamab Dose B in Combination With R2LenalidomideParticipants will receive epcoritamab Dose B in combination with lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days). Enrollment is closed for this arm.
Epcoritamab Dose A in Combination With R2LenalidomideParticipants will receive epcoritamab Dose A in combination with lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days).
Epcoritamab Dose B in Combination With R2RituximabParticipants will receive epcoritamab Dose B in combination with lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days). Enrollment is closed for this arm.
Lenalidomide and Rituximab (R2)LenalidomideParticipants will receive lenalidomide and rituximab (R2) for 12 cycles (each cycle is 28 days).
Primary Outcome Measures
NameTimeMethod
Progression-Free Survival (PFS)Up to approximately 5 years

PFS is defined as duration from the date of randomization to the date of disease progression determined by Lugano criteria by independent review committee (IRC) or death (whichever occurs first).

Secondary Outcome Measures
NameTimeMethod
Percentage of Participants Achieving Complete Response (CR)Up to approximately 5 years

Percentage of participants who achieve a CR determined per Lugano criteria, as assessed by the IRC prior to the initiation of subsequent anti-lymphoma therapy.

Overall Survival (OS)Up to approximately 8 years from randomization

Overall survival is defined as the duration from the date of randomization to the date of the participant's death.

Percentage of Participants Achieving Minimal Residual Disease (MRD) NegativityUp to approximately 5 years

MRD negativity rate is defined as the percentage of participants who achieve MRD negative status prior to the initiation of subsequent anti-lymphoma therapy.

Trial Locations

Locations (273)

University of Arkansas for Medical Sciences /ID# 227198

🇺🇸

Little Rock, Arkansas, United States

Beverly Hills Cancer Center /ID# 231535

🇺🇸

Beverly Hills, California, United States

Valkyrie Clinical Trials /ID# 268502

🇺🇸

Los Angeles, California, United States

Hawaii Cancer Care - Waterfront Plaza /ID# 262448

🇺🇸

Honolulu, Hawaii, United States

Our Lady Of The Lake Regional Medical Center /ID# 251393

🇺🇸

Baton Rouge, Louisiana, United States

University of Maryland, Baltimore /ID# 227191

🇺🇸

Baltimore, Maryland, United States

East Carolina University - Brody School of Medicine /ID# 227192

🇺🇸

Greenville, North Carolina, United States

University of Oklahoma, Stephenson Cancer Center /ID# 227325

🇺🇸

Oklahoma City, Oklahoma, United States

Hunan Cancer Hospital /ID# 232153

🇨🇳

Changsha, Hunan, China

Yunnan Cancer Hospital /ID# 232062

🇨🇳

Kunming, Yunnan, China

Fakultní nemocnice Hradec Králové - Sokolská /ID# 228269

🇨🇿

Hradec Králové, Hradec Kralove, Czechia

Universitaetsklinikum Carl Gustav Carus Dresden /ID# 229754

🇩🇪

Dresden, Sachsen, Germany

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 228458

🇮🇹

San Giovanni Rotondo, Foggia, Italy

Istituto Europeo Di Oncologia /ID# 227396

🇮🇹

Milan, Milano, Italy

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 229820

🇮🇹

Torino, Piemonte, Italy

Duplicate_Centro di Riferimento Oncologico /ID# 227395

🇮🇹

Aviano, Pordenone, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 230402

🇮🇹

Rome, Roma, Italy

Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo - Aless /ID# 227401

🇮🇹

Alessandria, Italy

Duplicate_I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 227400

🇮🇹

Bari, Italy

ASST degli Spedali Civili di Brescia /ID# 227397

🇮🇹

Brescia, Italy

Duplicate_Azienda Ospedaliera Universitaria Federico II /ID# 230403

🇮🇹

Napoli, Italy

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 227402

🇮🇹

Palermo, Italy

Ospedale Santa Maria Delle Croci /ID# 227394

🇮🇹

Ravenna, Italy

Matsuyama Red Cross Hospital /ID# 251866

🇯🇵

Matsuyama-shi, Ehime, Japan

Kitasato University Hospital /ID# 264668

🇯🇵

Sagamihara, Kanagawa, Japan

Olvg /Id# 247899

🇳🇱

Amsterdam, Noord-Holland, Netherlands

Hematology and Oncology Institute /ID# 230056

🇵🇷

Manati, Puerto Rico

Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi /ID# 248202

🇹🇷

Istanbul, Turkey

University of Arizona Cancer Center - North Campus /ID# 228862

🇺🇸

Tucson, Arizona, United States

Alta Bates Summit Medical Center for Research /ID# 229428

🇺🇸

Berkeley, California, United States

Long Beach Memorial Medical Ct /ID# 228997

🇺🇸

Long Beach, California, United States

University of Southern California /ID# 227195

🇺🇸

Los Angeles, California, United States

Emory University /ID# 227299

🇺🇸

Atlanta, Georgia, United States

Northwestern University Feinberg School of Medicine /ID# 227248

🇺🇸

Chicago, Illinois, United States

Goshen Center for Cancer Care /ID# 227189

🇺🇸

Goshen, Indiana, United States

Community Health Network, Inc. /ID# 259756

🇺🇸

Indianapolis, Indiana, United States

Massachusetts General Hospital /ID# 245233

🇺🇸

Boston, Massachusetts, United States

UMass Memorial Medical Center /ID# 227323

🇺🇸

Worcester, Massachusetts, United States

Henry Ford Hospital /ID# 227250

🇺🇸

Detroit, Michigan, United States

St. Luke's Hospital - Chesterfield /ID# 247817

🇺🇸

Chesterfield, Missouri, United States

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 251220

🇺🇸

Billings, Montana, United States

Morristown Medical Center /ID# 231427

🇺🇸

Morristown, New Jersey, United States

Roswell Park Cancer Institute /ID# 239128

🇺🇸

Buffalo, New York, United States

NYU Langone Hospital - Long Island /ID# 253343

🇺🇸

Mineola, New York, United States

NYU Laura and Isaac Perlmutter Cancer Center /ID# 227322

🇺🇸

New York, New York, United States

Icahn School of Medicine at Mount Sinai /ID# 227181

🇺🇸

New York, New York, United States

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 227193

🇺🇸

New York, New York, United States

Baylor Sammons Cancer Center /ID# 261584

🇺🇸

Dallas, Texas, United States

Texas Oncology - Northeast Texas /ID# 265890

🇺🇸

Tyler, Texas, United States

Intermountain Healthcare LDS Hospital /ID# 259948

🇺🇸

Salt Lake City, Utah, United States

Virginia Commonwealth University Medical Center Main Hospital /ID# 227211

🇺🇸

Richmond, Virginia, United States

Fundaleu /Id# 229700

🇦🇷

Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina

Cemic /Id# 229697

🇦🇷

Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina

Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 229701

🇦🇷

Cordoba, Argentina

Clinica de Nefrologia, Urologia y Enfermedades Cardiovasculares /ID# 232124

🇦🇷

Santa Fe, Argentina

Royal Prince Alfred Hospital /ID# 239272

🇦🇺

Camperdown, New South Wales, Australia

Nepean Hospital /ID# 239093

🇦🇺

Kingswood, New South Wales, Australia

Townsville University Hospital /ID# 231124

🇦🇺

Douglas, Queensland, Australia

Peninsula Private Hospital /ID# 238796

🇦🇺

Frankston, Victoria, Australia

Fiona Stanley Hospital /ID# 231122

🇦🇺

Murdoch, Western Australia, Australia

Royal Perth Hospital /ID# 230456

🇦🇺

Perth, Western Australia, Australia

Hollywood Private Hospital /ID# 251789

🇦🇺

Perth, Western Australia, Australia

Universitaetsklinikum St. Poelten /ID# 234015

🇦🇹

Sankt Poelten, Niederoesterreich, Austria

Ordensklinikum Linz GmbH Elisabethinen /ID# 247510

🇦🇹

Linz, Oberoesterreich, Austria

Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 228366

🇦🇹

Salzburg, Austria

Uza /Id# 228521

🇧🇪

Edegem, Antwerpen, Belgium

Hospital La Louviere Site Jolimont - Helora /ID# 228520

🇧🇪

La Louvière, Hainaut, Belgium

Vitaz /Id# 228525

🇧🇪

Sint-Niklaas, Oost-Vlaanderen, Belgium

Universitair Ziekenhuis Leuven /ID# 247780

🇧🇪

Leuven, Vlaams-Brabant, Belgium

Institut Jules Bordet /ID# 254676

🇧🇪

Anderlecht, Belgium

Groupe Sante CHC - Clinique du MontLegia /ID# 230415

🇧🇪

Liege, Belgium

AZ Turnhout - Campus Sint-Elisabeth /ID# 231628

🇧🇪

Turnhout, Belgium

Hospital de Clinicas da Universidade Federal do Parana /ID# 228123

🇧🇷

Curitiba, Parana, Brazil

Upeclin Fmb - Unesp /Id# 252912

🇧🇷

Botucatu, Sao Paulo, Brazil

Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 228129

🇧🇷

Jaú, Sao Paulo, Brazil

Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 228130

🇧🇷

São Paulo, Sao Paulo, Brazil

Instituto Nacional de Cancer (INCA) /ID# 228706

🇧🇷

Rio de Janeiro, Brazil

Real e Benemérita Associação Portuguesa de Beneficência /ID# 228121

🇧🇷

Sao Paulo, Brazil

Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 252918

🇧🇷

Sao Paulo, Brazil

Instituto de Assistencia Medica ao Servidor Publico Estadual /ID# 230182

🇧🇷

Sao Paulo, Brazil

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 228127

🇧🇷

Sao Paulo, Brazil

Cross Cancer Institute /ID# 249080

🇨🇦

Edmonton, Alberta, Canada

BC Cancer - Victoria /ID# 228850

🇨🇦

Victoria, British Columbia, Canada

CSSS Alphonse-Desjardins, CHAU de Levis /ID# 229896

🇨🇦

Levis, Quebec, Canada

CHUQ- Hôpital de l'Enfant-Jesus /ID# 231537

🇨🇦

Quebec City, Quebec, Canada

CISSSBSL -Hopital regional de Rimouski /ID# 229894

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Rimouski, Quebec, Canada

Peking University First Hospital /ID# 250517

🇨🇳

Beijing, Beijing, China

Peking University Third Hospital /ID# 230885

🇨🇳

Beijing, Beijing, China

Fujian Medical University Union Hospital /ID# 233919

🇨🇳

Fuzhou, Fujian, China

The First Affiliated Hospital of Xiamen University /ID# 238427

🇨🇳

Xiamen, Fujian, China

Sun Yat-Sen University Cancer Center /ID# 231463

🇨🇳

Guangzhou, Guangdong, China

Guangdong Provincial Peoples Hospital(Huifu Campus) /ID# 232512

🇨🇳

Guangzhou, Guangdong, China

Nanfang Hospital of Southern Medical University /ID# 230383

🇨🇳

Guangzhou, Guangdong, China

Fourth Hospital of Hebei Medical University /ID# 238657

🇨🇳

Shijiazhuang, Hebei, China

Henan Cancer Hospital /ID# 230459

🇨🇳

Zhengzhou, Henan, China

Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234153

🇨🇳

Wuhan, Hubei, China

Hubei Cancer Hospital /ID# 232255

🇨🇳

Wuhan, Hubei, China

The First Affiliated Hospital of Soochow University /ID# 232511

🇨🇳

Suzhou, Jiangsu, China

The Affiliated Hospital of Xuzhou Medical College /ID# 232513

🇨🇳

Xuzhou, Jiangsu, China

The First Affiliated Hospital of Nanchang University /ID# 231047

🇨🇳

Nanchang, Jiangxi, China

Jiangxi Provincial Cancer Hospital /ID# 232507

🇨🇳

Nanchang, Jiangxi, China

The First Hospital of China Medical University /ID# 232509

🇨🇳

Shenyang, Liaoning, China

Xijing Hospital /ID# 238650

🇨🇳

Xi'an, Shaanxi, China

Fudan University Cancer Hospital /ID# 250475

🇨🇳

Shanghai, Shanghai, China

Tianjin Cancer Hospital /ID# 230876

🇨🇳

Tianjin, Tianjin, China

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230390

🇨🇳

Hangzhou, Zhejiang, China

The second affiliated hospital of Zhejiang University school of medicine /ID# 231250

🇨🇳

Hangzhou, Zhejiang, China

Zhejiang Cancer hospital /ID# 231389

🇨🇳

Hangzhou, Zhejiang, China

Duplicate_Fakultni Nemocnice v Motole /ID# 228272

🇨🇿

Prague, Czechia

Fakultni nemocnice Kralovske Vinohrady /ID# 228564

🇨🇿

Praha, Czechia

Vseobecna fakultni nemocnice v Praze /ID# 228565

🇨🇿

Praha, Czechia

Regionshospitalet Godstrup /ID# 227466

🇩🇰

Herning, Midtjylland, Denmark

Sygehus Lillebalt, Vejle /ID# 227404

🇩🇰

Vejle, Syddanmark, Denmark

CHU Clermont-Ferrand /ID# 238676

🇫🇷

Clermont, Auvergne-Rhone-Alpes, France

CHU de Rennes - PONTCHAILLOU /ID# 230356

🇫🇷

Rennes, Bretagne, France

CHU Dijon /ID# 230354

🇫🇷

Dijon, Cote-d Or, France

CHU Limoges - Dupuytren 1 /ID# 231450

🇫🇷

Limoges CEDEX 1, Franche-Comte, France

CHU NIMES - Hopital Caremeau /ID# 230351

🇫🇷

Nimes CEDEX 9, Gard, France

Centre Hospitalier Universitaire de Bordeaux /ID# 230347

🇫🇷

Pessac CEDEX, Gironde, France

Hopital Pitie Salpetriere /ID# 230360

🇫🇷

Paris, Ile-de-France, France

CHU Reims - Hôpital Robert Debre /ID# 248710

🇫🇷

Reims CEDEX, Marne, France

CHRU Nancy - Hopitaux de Brabois /ID# 241595

🇫🇷

Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France

CHRU Lille - Hopital Claude Huriez /ID# 230353

🇫🇷

Lille, Nord, France

IUCT Oncopole /ID# 233486

🇫🇷

Toulouse Cedex 9, Occitanie, France

Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 230358

🇫🇷

Creteil, Paris, France

CHU de Nantes, Hotel Dieu -HME /ID# 245928

🇫🇷

Nantes, Pays-de-la-Loire, France

Centre Leon Berard /ID# 230348

🇫🇷

Lyon CEDEX 08, Rhone, France

HCL - Hopital Lyon Sud /ID# 231449

🇫🇷

Pierre Benite CEDEX, Rhone, France

CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 234095

🇫🇷

La Roche Sur Yon, Vendee, France

CHU Poitiers - La miletrie /ID# 230357

🇫🇷

Poitiers, Vienne, France

CHU de CAEN - Hopital de la Cote de Nacre /ID# 245929

🇫🇷

Caen, France

Hôpital Saint-Louis /ID# 232067

🇫🇷

Paris, France

Universitaetsklinikum Tuebingen /ID# 229663

🇩🇪

Tubingen, Baden-Wuerttemberg, Germany

Universitaetsklinikum Wuerzburg /ID# 229278

🇩🇪

Wuerzburg, Bayern, Germany

Universitaetsklinikum Giessen /ID# 234245

🇩🇪

Gießen, Hessen, Germany

Klinikum Kassel /ID# 229185

🇩🇪

Kassel, Hessen, Germany

Universitaetsmedizin Goettingen /ID# 230411

🇩🇪

Goettingen, Niedersachsen, Germany

Universitaetsklinikum Bonn /ID# 249401

🇩🇪

Bonn, Nordrhein-Westfalen, Germany

Universitaetsklinikum Leipzig /ID# 242907

🇩🇪

Leipzig, Sachsen, Germany

Universitaetsklinikum Jena /ID# 232064

🇩🇪

Jena, Thueringen, Germany

Sozialstiftung Bamberg /ID# 229184

🇩🇪

Bamberg, Germany

Helios Klinikum Berlin-Buch /ID# 229178

🇩🇪

Berlin, Germany

Universitaetsklinikum Essen /ID# 229180

🇩🇪

Essen, Germany

Otto-von-Guericke-Universitaet /ID# 230144

🇩🇪

Magdeburg, Germany

Klinikum Mutterhaus der Borromäerinnen /ID# 232354

🇩🇪

Trier, Germany

General Hospital of Athens Laiko /ID# 226626

🇬🇷

Athens, Attiki, Greece

Alexandra General Hospital /ID# 226632

🇬🇷

Athens, Attiki, Greece

University General Hospital Attikon /ID# 226629

🇬🇷

Athens, Attiki, Greece

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 226633

🇬🇷

Athens, Greece

University General Hospital of Ioannina /ID# 226628

🇬🇷

Ioannina, Greece

General University Hospital of Thessaloniki AXEPA /ID# 226630

🇬🇷

Thessaloniki, Greece

Theageneio Anticancer Hospital /ID# 226627

🇬🇷

Thessaloniki, Greece

Debreceni Egyetem-Klinikai Kozpont /ID# 229287

🇭🇺

Debrecen, Hajdu-Bihar, Hungary

Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 246475

🇭🇺

Kaposvár, Somogy, Hungary

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 232203

🇭🇺

Nyiregyhaza, Szabolcs-Szatmar-Bereg, Hungary

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 229290

🇭🇺

Szombathely, Vas, Hungary

Semmelweis Egyetem /ID# 229291

🇭🇺

Budapest, Hungary

Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 229286

🇭🇺

Budapest, Hungary

Orszagos Onkologiai Intezet /ID# 229292

🇭🇺

Budapest, Hungary

Szegedi Tudományegyetem /ID# 229289

🇭🇺

Szeged, Hungary

Rambam Health Care Campus /ID# 227849

🇮🇱

Haifa, H_efa, Israel

Yitzhak Shamir Medical Center /ID# 228037

🇮🇱

Zerifin, HaMerkaz, Israel

ZIV Medical Center /ID# 232257

🇮🇱

Safed, HaTsafon, Israel

The Chaim Sheba Medical Center /ID# 228322

🇮🇱

Ramat Gan, Tel-Aviv, Israel

Tel Aviv Sourasky Medical Center /ID# 228529

🇮🇱

Tel Aviv, Tel-Aviv, Israel

Hadassah /ID# 227846

🇮🇱

Jerusalem, Yerushalayim, Israel

Rabin Medical Center /ID# 228043

🇮🇱

Haifa, Israel

IRCCS Ospedale San Raffaele /ID# 228669

🇮🇹

Milan, Milano, Italy

Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 229602

🇮🇹

Candiolo, Torino, Italy

Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 227399

🇮🇹

Novara, Italy

NHO Nagoya Medical Center /ID# 230678

🇯🇵

Nagoya-shi, Aichi, Japan

Aichi Cancer Center Hospital /ID# 230134

🇯🇵

Nagoya-shi, Aichi, Japan

Fujita Health University Hospital /ID# 264541

🇯🇵

Toyoake, Aichi, Japan

National Cancer Center Hospital East /ID# 232423

🇯🇵

Kashiwa-shi, Chiba, Japan

National Hospital Organization Kyushu Cancer Center /ID# 252245

🇯🇵

Fukuoka-shi, Fukuoka, Japan

Kyushu University Hospital /ID# 230136

🇯🇵

Fukuoka-shi, Fukuoka, Japan

Fukushima Medical University Hospital /ID# 251839

🇯🇵

Fukushima-shi, Fukushima, Japan

Hokkaido University Hospital /ID# 231443

🇯🇵

Sapporo-shi, Hokkaido, Japan

Kobe City Medical Center General Hospital /ID# 251945

🇯🇵

Kobe-shi, Hyogo, Japan

Kagoshima University Hospital /ID# 232251

🇯🇵

Kagoshima-shi, Kagoshima, Japan

Tokai University Hospital /ID# 252135

🇯🇵

Isehara, Kanagawa, Japan

Kyoto University Hospital /ID# 231156

🇯🇵

Kyoto-shi, Kyoto, Japan

Mie University Hospital /ID# 251944

🇯🇵

Tsu-shi, Mie, Japan

Tohoku University Hospital /ID# 232303

🇯🇵

Sendai-shi, Miyagi, Japan

Shinshu University Hospital /ID# 252246

🇯🇵

Matsumoto-shi, Nagano, Japan

Okayama University Hospital /ID# 232009

🇯🇵

Okayama-shi, Okayama, Japan

Osaka City General Hospital /ID# 264670

🇯🇵

Osaka-shi, Osaka, Japan

Kindai University Hospital /ID# 232152

🇯🇵

Osakasayama-shi, Osaka, Japan

National Cancer Center Hospital /ID# 230004

🇯🇵

Chuo-ku, Tokyo, Japan

The Cancer Institute Hospital Of JFCR /ID# 230271

🇯🇵

Koto-ku, Tokyo, Japan

Yamagata University Hospital /ID# 230005

🇯🇵

Yamagata-shi, Yamagata, Japan

Yamanashi Prefectural Central Hospital /ID# 263715

🇯🇵

Kofu, Yamanashi, Japan

Inje University - Busan Paik Hospital /ID# 230293

🇰🇷

Busan, Busan Gwang Yeogsi, Korea, Republic of

Pusan National University Hospital /ID# 229798

🇰🇷

Busan, Busan Gwang Yeogsi, Korea, Republic of

Seoul National University Bundang Hospital /ID# 228448

🇰🇷

Seongnam-si, Gyeonggido, Korea, Republic of

Keimyung University Dongsan Hospital /ID# 229800

🇰🇷

Daegu, Gyeongsangbugdo, Korea, Republic of

Dong-A University Medical Center /ID# 228638

🇰🇷

Busan, Gyeongsangnamdo, Korea, Republic of

Jeonbuk National University Hospital /ID# 228908

🇰🇷

Jeonju, Jeonrabugdo, Korea, Republic of

Seoul National University Hospital /ID# 228446

🇰🇷

Seoul, Seoul Teugbyeolsi, Korea, Republic of

Asan Medical Center /ID# 228444

🇰🇷

Seoul, Seoul Teugbyeolsi, Korea, Republic of

Samsung Medical Center /ID# 228445

🇰🇷

Seoul, Seoul Teugbyeolsi, Korea, Republic of

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 228447

🇰🇷

Seoul, Seoul Teugbyeolsi, Korea, Republic of

Canisius-Wilhelmina Ziekenhuis /ID# 248138

🇳🇱

Nijmegen, Gelderland, Netherlands

Amphia Ziekenhuis /ID# 247739

🇳🇱

Breda, Noord-Brabant, Netherlands

Dijklander Ziekenhuis /ID# 248993

🇳🇱

Hoorn Nh, Noord-Holland, Netherlands

Medisch Spectrum Twente /ID# 247854

🇳🇱

Enschede, Overijssel, Netherlands

St. Antonius Ziekenhuis /ID# 248644

🇳🇱

Nieuwegein, Utrecht, Netherlands

Admiraal de Ruyter Ziekenhuis /ID# 247692

🇳🇱

Goes, Zeeland, Netherlands

Albert Schweitzer Ziekenhuis /ID# 247740

🇳🇱

Dordrecht, Zuid-Holland, Netherlands

Leids Universitair Medisch Centrum /ID# 247742

🇳🇱

Leiden, Zuid-Holland, Netherlands

Franciscus Gasthuis & Vlietland, Locatie Gasthuis /ID# 248139

🇳🇱

Rotterdam, Zuid-Holland, Netherlands

Deventer Ziekenhuis /ID# 247853

🇳🇱

Deventer, Netherlands

Universitair Medisch Centrum Groningen /ID# 247741

🇳🇱

Groningen, Netherlands

Aotearoa Clinical Trials /ID# 228509

🇳🇿

Papatoetoe, Auckland, New Zealand

North Shore Hospital /ID# 228508

🇳🇿

Takapuna, Auckland, New Zealand

Palmerston North Hospital /ID# 232352

🇳🇿

Palmerston North, Manawatu-Wanganui, New Zealand

Pratia MCM Krakow /ID# 229121

🇵🇱

Krakow, Malopolskie, Poland

Szpitale Pomorskie Sp. z o.o /ID# 229122

🇵🇱

Gdynia, Pomorskie, Poland

Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 229362

🇵🇱

Kielce, Swietokrzyskie, Poland

ARS-MEDICAL Sp. z o.o. /ID# 229601

🇵🇱

Pila, Wielkopolskie, Poland

Centrum Medyczne Pratia Poznan /ID# 229299

🇵🇱

Skorzewo, Wielkopolskie, Poland

Pan American Center for Oncology Trials, LLC /ID# 230055

🇵🇷

Rio Piedras, Puerto Rico

Auxilio Mutuo Cancer Center /ID# 248721

🇵🇷

San Juan, Puerto Rico

Narodny onkologicky ustav /ID# 239510

🇸🇰

Bratislava, Bratislavsky Kraj, Slovakia

Wits Clinical Research /ID# 228895

🇿🇦

Johannesburg, Gauteng, South Africa

Alberts Cellular Therapy /ID# 228896

🇿🇦

Pretoria, Gauteng, South Africa

University of Cape Town /ID# 228900

🇿🇦

Cape Town, Western Cape, South Africa

Haemalife Inc. /ID# 243392

🇿🇦

Kuilsrivier, Western Cape, South Africa

Instituto Catalan de Oncologia (ICO) Badalona /ID# 228108

🇪🇸

Badalona, Barcelona, Spain

Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 228107

🇪🇸

L'Hospitalet de Llobregat, Barcelona, Spain

Hospital Universitario Marques de Valdecilla /ID# 228984

🇪🇸

Santander, Cantabria, Spain

Hospital Universitario Reina Sofia /ID# 228122

🇪🇸

Córdoba, Cordoba, Spain

Clinica Universidad de Navarra - Pamplona /ID# 228116

🇪🇸

Pamplona, Navarra, Spain

Hospital Parc de Salut del Mar /ID# 228106

🇪🇸

Barcelona, Spain

Hospital Santa Creu i Sant Pau /ID# 229859

🇪🇸

Barcelona, Spain

Hospital San Pedro de Alcantara /ID# 248845

🇪🇸

Caceres, Spain

CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 229157

🇪🇸

Madrid, Spain

MD Anderson Madrid /ID# 229860

🇪🇸

Madrid, Spain

Hospital Universitario Ramon y Cajal /ID# 228113

🇪🇸

Madrid, Spain

Hospital Universitario Fundacion Jimenez Diaz /ID# 228110

🇪🇸

Madrid, Spain

Hospital Universitario 12 de Octubre /ID# 228109

🇪🇸

Madrid, Spain

Hospital Universitario de Salamanca /ID# 228117

🇪🇸

Salamanca, Spain

Hospital Universitario Virgen del Rocio /ID# 228118

🇪🇸

Sevilla, Spain

Sunderby sjukhus /ID# 228165

🇸🇪

Lulea, Norrbottens Lan, Sweden

Linkoping University Hospital /ID# 233520

🇸🇪

Linkoping, Ostergotlands Lan, Sweden

Sodra Alvsborgs sjukhus /ID# 228886

🇸🇪

Boras, Vastra Gotalands Lan, Sweden

Kantonsspital Aarau AG /ID# 229113

🇨🇭

Aarau, Aargau, Switzerland

Kantonsspital Graubunden /ID# 253862

🇨🇭

Chur, Graubuenden, Switzerland

Kantonsspital St. Gallen /ID# 229117

🇨🇭

St. Gallen, Sankt Gallen, Switzerland

EOC Ospedale Regionale di Bellinzona e Valli /ID# 228922

🇨🇭

Bellinzona, Ticino, Switzerland

Kaohsiung Chang Gung Memorial Hospital /ID# 227384

🇨🇳

Kaohsiung City, Kaohsiung, Taiwan

China Medical University Hospital /ID# 227379

🇨🇳

Taichung, Taiwan

Taichung Veterans General Hospital /ID# 227383

🇨🇳

Taichung, Taiwan

National Cheng Kung University Hospital /ID# 227381

🇨🇳

Tainan, Taiwan

Ankara Universitesi Fakultesi /ID# 227790

🇹🇷

Ankara, Turkey

Akdeniz Universitesi Tip Fakul /ID# 227791

🇹🇷

Antalya, Turkey

Dicle Universitesi Tip /ID# 230087

🇹🇷

Diyarbakir, Turkey

Istanbul Florence Nightingale Hastanesi /ID# 229546

🇹🇷

Istanbul, Turkey

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 227855

🇹🇷

Istanbul, Turkey

Ege University Medical Faculty /ID# 227792

🇹🇷

Izmir, Turkey

Kocaeli University Med Faculty /ID# 227854

🇹🇷

Kocaeli, Turkey

Ondokuz mayis University Facul /ID# 227794

🇹🇷

Samsun, Turkey

Derriford Hospital and the Royal Eye Infirmary /ID# 230038

🇬🇧

Plymouth, Devon, United Kingdom

Barts Health NHS Trust /ID# 230028

🇬🇧

London, Greater London, United Kingdom

Oxford University Hospitals NHS Foundation Trust /ID# 230035

🇬🇧

Oxford, Oxfordshire, United Kingdom

NHS Greater Glasgow and Clyde /ID# 230027

🇬🇧

Glasgow, Scotland, United Kingdom

Leeds Teaching Hospitals NHS Trust /ID# 230471

🇬🇧

Leeds, West Yorkshire, United Kingdom

University Hospitals Birmingham NHS Foundation Trust /ID# 230043

🇬🇧

Birmingham, United Kingdom

East Suffolk and North Essex NHS Foundation Trust /ID# 230040

🇬🇧

Colchester, United Kingdom

Clatterbridge Cancer Centre - Liverpool /ID# 230036

🇬🇧

Liverpool, United Kingdom

The Christie Hospital /ID# 230124

🇬🇧

Manchester, United Kingdom

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 230123

🇬🇧

Newcastle upon Tyne, United Kingdom

Portsmouth Hospitals University NHS Trust /ID# 230044

🇬🇧

Portsmouth, United Kingdom

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