A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Phase 3

Recruiting

• Conditions: Diffuse Large B-Cell Lymphoma
• Interventions: Drug: Epcoritamab; Drug: Cyclophosphamide; Drug: Rituximab; Drug: Vincristine; Drug: Doxorubicin; Drug: Prednisone

• Registration Number: NCT05578976
• Lead Sponsor: Genmab

Brief Summary

B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of this study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP...

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations
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Related News

Study Timeline

• Study First Submitted: 2022-10-12
• Study First Submitted QC: 2022-10-12
• Study First Posted: 2022-10-13
• Study Start: 2023-02-08
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-02
• Last Update Posted: 2024-12-04
• Primary Completion: 2027-06
• Study Completion: 2029-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 900

Inclusion Criteria

• Planned to receive treatment with 6 cycles of standard rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) per investigator determination.

• Must have newly diagnosed, histologically confirmed CD20+ diffuse large b-cell lymphoma [DLBCL] (de novo or histologically transformed from a diagnosis of follicular lymphoma) at most recent representative tumor biopsy based on the pathology report, with a World Health Organization (WHO) 2016 classification and including:

  • DLBCL, Not Otherwise Specified (NOS).
  • High grade B-cell lymphoma with MYC and BCL-2 and/or BCL-6 rearrangement with DLBCL morphology.
  • T-cell/histiocyte-rich large B-cell lymphoma.
  • Epstein Barr virus-positive DLBCL, NOS.
  • Follicular lymphoma Grade 3b.

Note: The local pathology report must be available at Screening to support CD20+ DLBCL histology.

Composite/intermediate histology with any of the following components is not allowed: high grade B-cell lymphoma, NOS; Hodgkin's lymphoma; primary mediastinal (thymic) large B-cell lymphoma; Burkitt; plasmablastic lymphoma or any CD20- lymphoma, such as anaplastic lymphoma kinase-positive large B-cell lymphoma, human herpesvirus type 8-positive DLBCL, or primary effusion lymphoma.

• Availability of archival or fresh or paraffin embedded tissue at Screening.

• Must have an IPI score of 2-5. The number of participants with IPI 2 will not exceed approximately 30% of the overall sample size.

• Must have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 prior to initiating R-CHOP treatment. Note that participant with an initial ECOG performance status >= 3 may be screened if pre-phase treatment is planned. Participant may be eligible if ECOG performance status were to improve to 0-2 during pre-phase treatment.

• Has at least one target lesion defined as:

  • >= 1 measurable nodal lesion (long axis > 1.5 cm ) or >= 1 measurable extra-nodal lesion (long axis > 1 cm) on computed tomography (CT) scan or magnetic resonance imaging (MRI). AND
  • Positron emission tomography (PET)-positive on PET-CT scan.

• Laboratory values meeting the criteria laid out in the protocol.

• Left ventricular ejection fraction must be >= 50% by multi-gated acquisition or transthoracic echocardiography at Screening.

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Exclusion Criteria

• History of prior systemic anti-lymphoma therapy for diagnosed diffuse large b-cell lymphoma (DLBCL) including any definitive radiotherapy with curative intent] other than corticosteroids with or without vincristine during prephase treatment, or non-curative intent palliative radiotherapy with the stipulation that radiated lesions cannot be selected as target lesion for response assessment.
• Clinically significant cardiovascular disease as per the protocol.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Epcoritamab and R-CHOP	Epcoritamab	Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.
Epcoritamab and R-CHOP	Rituximab	Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.
Epcoritamab and R-CHOP	Cyclophosphamide	Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.
Epcoritamab and R-CHOP	Vincristine	Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.
Epcoritamab and R-CHOP	Doxorubicin	Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.
Epcoritamab and R-CHOP	Prednisone	Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.
R-CHOP and Rituximab	Cyclophosphamide	Participants will receive intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by intravenous rituximab in 21-day cycles.
R-CHOP and Rituximab	Rituximab	Participants will receive intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by intravenous rituximab in 21-day cycles.
R-CHOP and Rituximab	Vincristine	Participants will receive intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by intravenous rituximab in 21-day cycles.
R-CHOP and Rituximab	Prednisone	Participants will receive intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by intravenous rituximab in 21-day cycles.
R-CHOP and Rituximab	Doxorubicin	Participants will receive intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by intravenous rituximab in 21-day cycles.

Primary Outcome Measures

Name	Time	Method
Number of Participants with Progression-Free Survival (PFS) with an International Prognostic Index (IPI) of 3-5	Up to Approximately 46 Months	PFS is defined as the duration from randomization to the date of disease progression as determined by Lugano 2014 criteria as assessed by Independent Review Committee (IRC), or death due to any cause whichever comes first.

Secondary Outcome Measures

Name	Time	Method
Percentage of Participants with Complete Remission (CR)	On or After to Approximately 28 Weeks	CR on or after EOT, determined by Lugano 2014 criteria as assessed by IRC.
Overall survival (OS)	Up to Approximately 76 Months	OS is defined as time from randomization until death due to any causes.
Number of Participants with PFS	Up to Approximately 46 Months	PFS is defined as the duration from randomization to the date of disease progression as determined by Lugano 2014 criteria as assessed by IRC, or death due to any cause, whichever occurs first.
Number of Participants with Event-free survival (EFS)	Up to Approximately 46 Months	EFS is defined as the duration from randomization to the date of disease progression determined by Lugano criteria as assessed by IRC, IRC-assessed PR or SD followed by non protocol-specified NALT, a positive biopsy on or after end-of-treatment (EOT), regardless of whether NAL initiated, or death from any cause.
Percentage of Participants with Minimal Residual Disease (MRD) Negativity	Up to Approximately 46 Months	The MRD negativity rate is defined as the percentage of participants who achieve MRD negativity prior to the initiation of any non-protocol-specified new anti-lymphoma therapy.

Trial Locations

Locations (329)

Orlando Health Cancer Institute /ID# 232626; 🇺🇸 Orlando, Florida, United States

University of Illinois at Chicago /ID# 226889; 🇺🇸 Chicago, Illinois, United States

University of Maryland, Baltimore /ID# 225421; 🇺🇸 Baltimore, Maryland, United States

University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 225462; 🇺🇸 Ann Arbor, Michigan, United States

MDACC Cooper /ID# 260320; 🇺🇸 Camden, New Jersey, United States

Morristown Medical Center /ID# 239457; 🇺🇸 Morristown, New Jersey, United States

OhioHealth Arthur G.H. Bing, MD Cancer Center /ID# 260790; 🇺🇸 Columbus, Ohio, United States

University of Oklahoma, Stephenson Cancer Center /ID# 225556; 🇺🇸 Oklahoma City, Oklahoma, United States

Houston Methodist Hospital /ID# 258957; 🇺🇸 Houston, Texas, United States

Virginia Commonwealth University Medical Center Main Hospital /ID# 225796; 🇺🇸 Richmond, Virginia, United States

Duplicate_ZAS Middelheim /ID# 225741; 🇧🇪 Antwerp, Antwerpen, Belgium

ZAS Cadix /ID# 264327; 🇧🇪 Antwerp, Antwerpen, Belgium

Fakultní Nemocnice Brno - Jihlavská /ID# 225953; 🇨🇿 Brno, Brno-mesto, Czechia

Fakultní nemocnice Hradec Králové - Sokolská /ID# 225955; 🇨🇿 Hradec Králové, Hradec Kralove, Czechia

IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 225551; 🇮🇹 Bologna, Emilia-Romagna, Italy

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 225554; 🇮🇹 San Giovanni Rotondo, Foggia, Italy

Istituto Europeo Di Oncologia /ID# 225545; 🇮🇹 Milan, Milano, Italy

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 225775; 🇮🇹 Torino, Piemonte, Italy

Duplicate_Centro di Riferimento Oncologico /ID# 225553; 🇮🇹 Aviano, Pordenone, Italy

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 252192; 🇮🇹 Meldola, Reggio Emilia, Italy

Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo - Aless /ID# 225542; 🇮🇹 Alessandria, Italy

Duplicate_ASST Spedali civili di Brescia /ID# 225549; 🇮🇹 Brescia, Italy

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 225541; 🇮🇹 Palermo, Italy

Ospedale Santa Maria Delle Croci /ID# 225571; 🇮🇹 Ravenna, Italy

Matsuyama Red Cross Hospital /ID# 251068; 🇯🇵 Matsuyama-shi, Ehime, Japan

Duplicate_Hokkaido University Hospital /ID# 250149; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Olvg /Id# 229761; 🇳🇱 Amsterdam, Noord-Holland, Netherlands

Unidade Local de Saude de Santa Maria, EPE /ID# 249111; 🇵🇹 Lisboa, Portugal

Hammersmith Hospital /ID# 242215; 🇬🇧 London, England, United Kingdom

University of Arizona Cancer Center - North Campus /ID# 227463; 🇺🇸 Tucson, Arizona, United States

Yuma Regional Medical Center /ID# 261527; 🇺🇸 Yuma, Arizona, United States

University of Arkansas for Medical Sciences /ID# 225703; 🇺🇸 Little Rock, Arkansas, United States

CBCC Global Research, Inc. /ID# 262037; 🇺🇸 Bakersfield, California, United States

Alta Bates Summit Medical Center for Research /ID# 229427; 🇺🇸 Berkeley, California, United States

Orange Coast Memorial Medical Center /ID# 229632; 🇺🇸 Fountain Valley, California, United States

Providence - St. Jude Medical Center /ID# 262042; 🇺🇸 Fullerton, California, United States

Saddleback Memorial Medical Center /ID# 229631; 🇺🇸 Laguna Hills, California, United States

Long Beach Memorial Medical Ct /ID# 228996; 🇺🇸 Long Beach, California, United States

Cancer and Blood Speciality Clinic - Los Alamitos /ID# 262032; 🇺🇸 Los Alamitos, California, United States

University of Southern California /ID# 225443; 🇺🇸 Los Angeles, California, United States

University of California, Los Angeles /ID# 226887; 🇺🇸 Los Angeles, California, United States

Kaiser Permanente, Waterpark III Institute for Health Research /ID# 228618; 🇺🇸 Aurora, Colorado, United States

Cancer Specialists of North Florida /ID# 226826; 🇺🇸 Jacksonville, Florida, United States

Ocala Oncology Florida Cancer Affiliates - Main /ID# 262785; 🇺🇸 Ocala, Florida, United States

Straub Medical Center /ID# 229464; 🇺🇸 Honolulu, Hawaii, United States

Southern IL Univ School of Med /ID# 228999; 🇺🇸 Springfield, Illinois, United States

Springfield Clinic Main Campus /ID# 262584; 🇺🇸 Springfield, Illinois, United States

Carle Cancer Institute /ID# 228338; 🇺🇸 Urbana, Illinois, United States

New York Cancer and Blood Specialists- New Hyde Park /ID# 265392; 🇺🇸 New Hyde Park, New York, United States

Parkview Comprehensive Cancer Center /ID# 227026; 🇺🇸 Fort Wayne, Indiana, United States

Goshen Center for Cancer Care /ID# 225534; 🇺🇸 Goshen, Indiana, United States

Mission Cancer and Blood /ID# 261945; 🇺🇸 Des Moines, Iowa, United States

Cancer Center of Kansas /ID# 261983; 🇺🇸 Wichita, Kansas, United States

Norton Cancer Institute - St. Matthews /ID# 225420; 🇺🇸 Louisville, Kentucky, United States

Johns Hopkins Hospital /ID# 225369; 🇺🇸 Baltimore, Maryland, United States

American Oncology Partners of Maryland /ID# 226859; 🇺🇸 Bethesda, Maryland, United States

UMass Memorial Medical Center /ID# 226939; 🇺🇸 Worcester, Massachusetts, United States

Trinity Health St. Joseph Mercy Ann Arbor /ID# 228206; 🇺🇸 Ypsilanti, Michigan, United States

Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 226680; 🇺🇸 Saint Louis Park, Minnesota, United States

University of Mississippi Medical Center /ID# 228045; 🇺🇸 Jackson, Mississippi, United States

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 259014; 🇺🇸 Billings, Montana, United States

NHO Revive Research Institute, LLC /ID# 261113; 🇺🇸 Lincoln, Nebraska, United States

Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 226654; 🇺🇸 East Brunswick, New Jersey, United States

University of New Mexico /ID# 227332; 🇺🇸 Albuquerque, New Mexico, United States

Presbyterian Kaseman Hospital /ID# 262084; 🇺🇸 Albuquerque, New Mexico, United States

Presbyterian Rust Medical Center /ID# 262068; 🇺🇸 Rio Rancho, New Mexico, United States

New York Cancer and Blood Specialists- Eastchester, Bronx /ID# 265396; 🇺🇸 Bronx, New York, United States

Roswell Park Cancer Institute /ID# 239127; 🇺🇸 Buffalo, New York, United States

NYU Langone Hospital - Long Island /ID# 262412; 🇺🇸 Mineola, New York, United States

NYU Langone - Laura and Isaac Perlmutter Cancer Center /ID# 226141; 🇺🇸 New York, New York, United States

New York Cancer and Blood Specialists- Manhattan /ID# 265391; 🇺🇸 New York, New York, United States

Icahn School of Medicine at Mount Sinai /ID# 225370; 🇺🇸 New York, New York, United States

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 225379; 🇺🇸 New York, New York, United States

New York Cancer and Blood Specialists /ID# 261114; 🇺🇸 Port Jefferson Station, New York, United States

Novant Health Presbyterian Medical Center /ID# 227753; 🇺🇸 Charlotte, North Carolina, United States

East Carolina University - Brody School of Medicine /ID# 225992; 🇺🇸 Greenville, North Carolina, United States

Novant Health Forsyth Medical Center /ID# 228339; 🇺🇸 Winston-Salem, North Carolina, United States

University of Cincinnati /ID# 225374; 🇺🇸 Cincinnati, Ohio, United States

Kaiser Permanente - Northwest /ID# 225488; 🇺🇸 Portland, Oregon, United States

Millennium Research & Clinical Development /ID# 228284; 🇺🇸 Kingwood, Texas, United States

Joe Arrington Cancer Research /ID# 227217; 🇺🇸 Lubbock, Texas, United States

Baylor Scott & White Medical Center- Temple /ID# 225935; 🇺🇸 Temple, Texas, United States

Intermountain Medical Center /ID# 231184; 🇺🇸 Murray, Utah, United States

University of Virginia Cancer Center - West Complex /ID# 225433; 🇺🇸 Charlottesville, Virginia, United States

Vista Oncology - East Olympia /ID# 229375; 🇺🇸 Olympia, Washington, United States

Royal Perth Hospital /ID# 226583; 🇦🇺 Perth, Western Australia, Australia

MultiCare Institute for Research & Innovation /ID# 225432; 🇺🇸 Tacoma, Washington, United States

MultiCare Regional Cancer Center - Tacoma /ID# 265285; 🇺🇸 Tacoma, Washington, United States

Liverpool Hospital /ID# 230072; 🇦🇺 Liverpool, New South Wales, Australia

Royal Adelaide Hospital /ID# 225683; 🇦🇺 Adelaide, South Australia, Australia

Monash Medical Centre /ID# 225680; 🇦🇺 Clayton, Victoria, Australia

Austin Health /ID# 225716; 🇦🇺 Heidelberg, Victoria, Australia

The Alfred Hospital /ID# 225999; 🇦🇺 Melbourne, Victoria, Australia

Hollywood Private Hospital /ID# 251837; 🇦🇺 Nedlands, Western Australia, Australia

Perth Blood Institute Ltd /ID# 225679; 🇦🇺 Nedlands, Western Australia, Australia

Universitaetsklinikum St. Poelten /ID# 234016; 🇦🇹 Sankt Poelten, Niederoesterreich, Austria

Medizinische Universitaet Wien /ID# 252095; 🇦🇹 Vienna, Wien, Austria

Klinik Ottakring /ID# 243941; 🇦🇹 Vienna, Wien, Austria

Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 228360; 🇦🇹 Salzburg, Austria

Cliniques Universitaires UCL Saint-Luc /ID# 225737; 🇧🇪 Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium

Hospital La Louviere Site Jolimont - Helora /ID# 225738; 🇧🇪 La Louvière, Hainaut, Belgium

CHU de Liège /ID# 225952; 🇧🇪 Liège, Liege, Belgium

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 225742; 🇧🇪 Yvoir, Namur, Belgium

UZ Gent /ID# 250031; 🇧🇪 Gent, Oost-Vlaanderen, Belgium

Vitaz /Id# 226153; 🇧🇪 Sint-Niklaas, Oost-Vlaanderen, Belgium

Universitair Ziekenhuis Leuven /ID# 225951; 🇧🇪 Leuven, Vlaams-Brabant, Belgium

AZ-Delta /ID# 225736; 🇧🇪 Roeselare, West-Vlaanderen, Belgium

Institut Jules Bordet /ID# 225954; 🇧🇪 Anderlecht, Belgium

AZ Sint-Jan Brugge /ID# 225735; 🇧🇪 Brugge, Belgium

Hospital de Clinicas da Universidade Federal do Parana /ID# 226027; 🇧🇷 Curitiba, Parana, Brazil

Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 226065; 🇧🇷 Jaú, Sao Paulo, Brazil

Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 226809; 🇧🇷 São Paulo, Sao Paulo, Brazil

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein /ID# 252832; 🇧🇷 São Paulo, Sao Paulo, Brazil

Instituto Nacional de Cancer (INCA) /ID# 226026; 🇧🇷 Rio de Janeiro, Brazil

Real e Benemérita Associação Portuguesa de Beneficência /ID# 226023; 🇧🇷 Sao Paulo, Brazil

Hospital Alemao Oswaldo Cruz /ID# 252833; 🇧🇷 Sao Paulo, Brazil

Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 262394; 🇧🇷 Sao Paulo, Brazil

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 226048; 🇧🇷 Sao Paulo, Brazil

UMHAT Sveti Georgi /ID# 245780; 🇧🇬 Plovdiv, Bulgaria

Acibadem City Clinic Tokuda University Hospital EAD /ID# 244616; 🇧🇬 Sofia, Bulgaria

UMHAT Sveti Ivan Rilski /ID# 244615; 🇧🇬 Sofia, Bulgaria

SHAT Hematologic Diseases /ID# 250102; 🇧🇬 Sofia, Bulgaria

Tom Baker Cancer Centre /ID# 226077; 🇨🇦 Calgary, Alberta, Canada

BC Cancer - Vancouver /ID# 230573; 🇨🇦 Vancouver, British Columbia, Canada

William Osler Health System /ID# 250973; 🇨🇦 Brampton, Ontario, Canada

Juravinski Cancer Centre /ID# 226084; 🇨🇦 Hamilton, Ontario, Canada

Saskatoon Cancer Centre /ID# 226082; 🇨🇦 Saskatoon, Saskatchewan, Canada

The Fifth Medical Center of PLA General Hospital /ID# 230941; 🇨🇳 Beijing, Beijing, China

Beijing Cancer Hospital /ID# 229819; 🇨🇳 Beijing, Beijing, China

Peking University Third Hospital /ID# 230975; 🇨🇳 Beijing, Beijing, China

Fujian Provincial Cancer Hospital /ID# 238430; 🇨🇳 Fuzhou, Fujian, China

The First Affiliated Hospital of Xiamen University /ID# 238426; 🇨🇳 Xiamen, Fujian, China

Sun Yat-Sen University Cancer Center /ID# 238371; 🇨🇳 Guangzhou, Guangdong, China

Guangdong Provincial People's Hospital /ID# 230945; 🇨🇳 Guangzhou, Guangdong, China

Nanfang Hospital of Southern Medical University /ID# 238436; 🇨🇳 Guangzhou, Guangdong, China

Fourth Hospital of Hebei Medical University /ID# 238656; 🇨🇳 Shijiazhuang, Hebei, China

Harbin Medical University Cancer Hospital /Id# 241755; 🇨🇳 Harbin, Heilongjiang, China

Henan Cancer Hospital /ID# 230398; 🇨🇳 Zhengzhou, Henan, China

Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234152; 🇨🇳 Wuhan, Hubei, China

Hubei Cancer Hospital /ID# 232256; 🇨🇳 Wuhan, Hubei, China

The First Affiliated Hospital of Soochow University /ID# 232569; 🇨🇳 Suzhou, Jiangsu, China

The Affiliated Hospital of Xuzhou Medical College /ID# 233174; 🇨🇳 Xuzhou, Jiangsu, China

The First Affiliated Hospital of Nanchang University /ID# 230399; 🇨🇳 Nanchang, Jiangxi, China

Jiangxi Provincial Cancer Hospital /ID# 233379; 🇨🇳 Nanchang, Jiangxi, China

The First Hospital of Jilin University /ID# 239618; 🇨🇳 Changchun, Jilin, China

The First Hospital of China Medical University /ID# 233201; 🇨🇳 Shenyang, Liaoning, China

Shandong Cancer Hospital /ID# 233200; 🇨🇳 Jinan, Shandong, China

Fudan University Cancer Hospital /ID# 251516; 🇨🇳 Shanghai, Shanghai, China

Shanxi Provincial Cancer Hospital /ID# 250745; 🇨🇳 Taiyuan, Shanxi, China

Tianjin Cancer Hospital /ID# 230974; 🇨🇳 Tianjin, Tianjin, China

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 259904; 🇨🇳 Tianjin, Tianjin, China

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230387; 🇨🇳 Hangzhou, Zhejiang, China

The second affiliated hospital of Zhejiang University school of medicine /ID# 231249; 🇨🇳 Hangzhou, Zhejiang, China

Zhejiang Cancer hospital /ID# 231388; 🇨🇳 Hangzhou, Zhejiang, China

Clinical Hospital Dubrava /ID# 251809; 🇭🇷 Zagreb, Grad Zagreb, Croatia

Klinicka bolnica Merkur /ID# 252481; 🇭🇷 Zagreb, Grad Zagreb, Croatia

Klinicki bolnicki centar Zagreb /ID# 250709; 🇭🇷 Zagreb, Grad Zagreb, Croatia

Klinicki bolnicki centar Rijeka /ID# 251811; 🇭🇷 Rijeka, Primorsko-goranska Zupanija, Croatia

Klinicki Bolnicki Centar (KBC) Split /ID# 250729; 🇭🇷 Split, Splitsko-dalmatinska Zupanija, Croatia

Opca bolnica Dr. Josip Bencevic /ID# 251812; 🇭🇷 Slavonski Brod, Croatia

Fakultni Nemocnice Ostrava /ID# 225957; 🇨🇿 Ostrava, Ostrava-mesto, Czechia

Duplicate_Fakultni Nemocnice v Motole /ID# 225958; 🇨🇿 Prague, Czechia

Fakultni nemocnice Kralovske Vinohrady /ID# 225956; 🇨🇿 Praha, Czechia

Vseobecna fakultni nemocnice v Praze /ID# 225396; 🇨🇿 Praha, Czechia

Rigshospitalet /ID# 226576; 🇩🇰 Copenhagen Ø, Hovedstaden, Denmark

Aarhus Universitetshospital - Skejby /ID# 226594; 🇩🇰 Aarhus, Midtjylland, Denmark

Roskilde Sygehus /ID# 226597; 🇩🇰 Roskilde, Sjælland, Denmark

Odense University Hospital /ID# 226593; 🇩🇰 Odense, Syddanmark, Denmark

Sygehus Lillebalt, Vejle /ID# 226592; 🇩🇰 Vejle, Syddanmark, Denmark

CHU de Nice - Hôpital Archet 1 /ID# 226127; 🇫🇷 Nice, Alpes-Maritimes, France

Institut Paoli-Calmettes /ID# 226557; 🇫🇷 Marseille, Bouches-du-Rhone, France

CHU de Rennes - PONTCHAILLOU /ID# 228207; 🇫🇷 Rennes, Bretagne, France

CHU Dijon /ID# 238345; 🇫🇷 Dijon, Cote-d Or, France

CHU Limoges - Dupuytren 1 /ID# 234235; 🇫🇷 Limoges CEDEX 1, Franche-Comte, France

CHU Montpellier - Hopital Saint Eloi /ID# 228191; 🇫🇷 Montpellier Cedex 5, Herault, France

CHU Grenoble - Hopital Michallon /ID# 226128; 🇫🇷 La Tronche, Isere, France

CHRU Nancy - Hopitaux de Brabois /ID# 226102; 🇫🇷 Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France

CHRU Lille - Hopital Claude Huriez /ID# 226101; 🇫🇷 Lille, Nord, France

Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 226560; 🇫🇷 Creteil, Paris, France

CHU de Nantes, Hotel Dieu -HME /ID# 226125; 🇫🇷 Nantes, Pays-de-la-Loire, France

Centre Hospitalier de la Cote Basque /ID# 249143; 🇫🇷 Bayonne, Pyrenees-Atlantiques, France

HCL - Hopital Lyon Sud /ID# 227086; 🇫🇷 Pierre Benite CEDEX, Rhone, France

Centre Henri Becquerel /ID# 226103; 🇫🇷 Rouen, Seine-Maritime, France

CHU Amiens-Picardie Site Sud /ID# 238347; 🇫🇷 Amiens CEDEX 1, Somme, France

CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 243899; 🇫🇷 La Roche Sur Yon, Vendee, France

CHU Poitiers - La miletrie /ID# 226578; 🇫🇷 Poitiers, Vienne, France

Chu Angers /Id# 245931; 🇫🇷 Angers, France

CHU de CAEN - Hopital de la Cote de Nacre /ID# 226582; 🇫🇷 Caen, France

Hôpital Saint-Louis /ID# 226126; 🇫🇷 Paris, France

Institut Curie - site CLCC René Huguenin /ID# 253519; 🇫🇷 Saint-cloud, France

General Hospital of Athens Laiko /ID# 225399; 🇬🇷 Athens, Attiki, Greece

Alexandra General Hospital /ID# 225402; 🇬🇷 Athens, Attiki, Greece

University General Hospital Attikon /ID# 225401; 🇬🇷 Athens, Attiki, Greece

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 225416; 🇬🇷 Athens, Greece

University General Hospital of Ioannina /ID# 225400; 🇬🇷 Ioannina, Greece

General University Hospital of Thessaloniki AXEPA /ID# 225398; 🇬🇷 Thessaloniki, Greece

Theageneio Anticancer Hospital /ID# 225516; 🇬🇷 Thessaloniki, Greece

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 257189; 🇭🇺 Gyor, Gyor-Moson-Sopron, Hungary

Debreceni Egyetem-Klinikai Kozpont /ID# 226821; 🇭🇺 Debrecen, Hajdu-Bihar, Hungary

Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 245938; 🇭🇺 Kaposvár, Somogy, Hungary

Tolna Varmegyei Balassa Janos Korhaz /ID# 250063; 🇭🇺 Szekszard, Tolna, Hungary

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 226846; 🇭🇺 Szombathely, Vas, Hungary

Semmelweis Egyetem /ID# 227239; 🇭🇺 Budapest, Hungary

Orszagos Onkologiai Intezet /ID# 227294; 🇭🇺 Budapest, Hungary

Szegedi Tudományegyetem /ID# 226838; 🇭🇺 Szeged, Hungary

Rambam Health Care Campus /ID# 225981; 🇮🇱 Haifa, H_efa, Israel

Meir Medical Center /ID# 225612; 🇮🇱 Kfar Saba, HaMerkaz, Israel

Assuta Tel Aviv Medical Center /ID# 226066; 🇮🇱 Tel Aviv, HaMerkaz, Israel

The Chaim Sheba Medical Center /ID# 225600; 🇮🇱 Ramat Gan, Tel-Aviv, Israel

Tel Aviv Sourasky Medical Center /ID# 225891; 🇮🇱 Tel Aviv, Tel-Aviv, Israel

Shaare Zedek Medical Center /ID# 259796; 🇮🇱 Jerusalem, Yerushalayim, Israel

Hadassah /ID# 225614; 🇮🇱 Jerusalem, Yerushalayim, Israel

Rabin Medical Center /ID# 225862; 🇮🇱 Haifa, Israel

IRCCS Ospedale San Raffaele /ID# 225555; 🇮🇹 Milan, Milano, Italy

Azienda Ospedaliera Universitaria Federico II /ID# 225543; 🇮🇹 Naples, Napoli, Italy

Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 225751; 🇮🇹 Candiolo, Torino, Italy

I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 225548; 🇮🇹 Bari, Italy

Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 225773; 🇮🇹 Novara, Italy

Azienda Ospedaliero Universitaria Pisana /ID# 225575; 🇮🇹 Pisa, Italy

NHO Nagoya Medical Center /ID# 230677; 🇯🇵 Nagoya-shi, Aichi, Japan

Aichi Cancer Center Hospital /ID# 226090; 🇯🇵 Nagoya-shi, Aichi, Japan

National Cancer Center Hospital East /ID# 250151; 🇯🇵 Kashiwa-shi, Chiba, Japan

National Hospital Organization Kyushu Cancer Center /ID# 251622; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

Kyushu University Hospital /ID# 226091; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

Fukushima Medical University Hospital /ID# 250869; 🇯🇵 Fukushima-shi, Fukushima, Japan

Kobe City Medical Center General Hospital /ID# 250597; 🇯🇵 Kobe-shi, Hyogo, Japan

University of Tsukuba Hospital /ID# 251282; 🇯🇵 Tsukuba-shi, Ibaraki, Japan

Kanazawa University Hospital /ID# 251770; 🇯🇵 Kanazawa-shi, Ishikawa, Japan

Kagoshima University Hospital /ID# 250163; 🇯🇵 Kagoshima-shi, Kagoshima, Japan

Tokai University Hospital /ID# 251281; 🇯🇵 Isehara, Kanagawa, Japan

Tohoku University Hospital /ID# 250150; 🇯🇵 Sendai-shi, Miyagi, Japan

Okayama University Hospital /ID# 250161; 🇯🇵 Okayama-shi, Okayama, Japan

Kindai University Hospital /ID# 250160; 🇯🇵 Osakasayama-shi, Osaka, Japan

Osaka University Hospital /ID# 251283; 🇯🇵 Suita-shi, Osaka, Japan

National Cancer Center Hospital /ID# 226089; 🇯🇵 Chuo-ku, Tokyo, Japan

The Cancer Institute Hospital Of JFCR /ID# 230269; 🇯🇵 Koto-ku, Tokyo, Japan

Yamagata University Hospital /ID# 230003; 🇯🇵 Yamagata-shi, Yamagata, Japan

Inje University - Busan Paik Hospital /ID# 232262; 🇰🇷 Busan, Busan Gwang Yeogsi, Korea, Republic of

Seoul National University Bundang Hospital /ID# 225763; 🇰🇷 Seongnam-si, Gyeonggido, Korea, Republic of

Keimyung University Dongsan Hospital /ID# 232264; 🇰🇷 Daegu, Gyeongsangbugdo, Korea, Republic of

Dong-A University Medical Center /ID# 228451; 🇰🇷 Busan, Gyeongsangnamdo, Korea, Republic of

Jeonbuk National University Hospital /ID# 232263; 🇰🇷 Jeonju, Jeonrabugdo, Korea, Republic of

Seoul National University Hospital /ID# 225760; 🇰🇷 Seoul, Seoul Teugbyeolsi, Korea, Republic of

Asan Medical Center /ID# 225758; 🇰🇷 Seoul, Seoul Teugbyeolsi, Korea, Republic of

Samsung Medical Center /ID# 225759; 🇰🇷 Seoul, Seoul Teugbyeolsi, Korea, Republic of

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 225761; 🇰🇷 Seoul, Seoul Teugbyeolsi, Korea, Republic of

Ulsan University Hospital /ID# 226971; 🇰🇷 Ulsan, Ulsan Gwang Yeogsi, Korea, Republic of

Flevo Ziekenhuis /ID# 229606; 🇳🇱 Almere, Flevoland, Netherlands

Medisch Centrum Leeuwarden /ID# 225605; 🇳🇱 Leeuwarden, Friesland, Netherlands

Gelre Ziekenhuizen /ID# 229762; 🇳🇱 Apeldoorn, Gelderland, Netherlands

Canisius-Wilhelmina Ziekenhuis /ID# 231291; 🇳🇱 Nijmegen, Gelderland, Netherlands

Maastricht Universitair Medisch Centrum /ID# 225607; 🇳🇱 Maastricht, Limburg, Netherlands

Amphia Ziekenhuis /ID# 229550; 🇳🇱 Breda, Noord-Brabant, Netherlands

Catharina Ziekenhuis /ID# 230465; 🇳🇱 Eindhoven, Noord-Brabant, Netherlands

Maxima Medisch Centrum /ID# 225603; 🇳🇱 Eindhoven, Noord-Brabant, Netherlands

Elisabeth Tweesteden Ziekenhuis /ID# 229773; 🇳🇱 Tilburg, Noord-Brabant, Netherlands

Noordwest Ziekenhuisgroep /ID# 230613; 🇳🇱 Alkmaar, Noord-Holland, Netherlands

Vrije Universiteit Medisch Centrum /ID# 225608; 🇳🇱 Amsterdam, Noord-Holland, Netherlands

Spaarne Gasthuis, Haarlem Zuid /ID# 229621; 🇳🇱 Haarlem, Noord-Holland, Netherlands

Tergooi /ID# 229772; 🇳🇱 Hilversum, Noord-Holland, Netherlands

Dijklander Ziekenhuis /ID# 229900; 🇳🇱 Hoorn Nh, Noord-Holland, Netherlands

Zaans Medisch Centrum /ID# 230614; 🇳🇱 Zaandam, Noord-Holland, Netherlands

Medisch Spectrum Twente /ID# 225610; 🇳🇱 Enschede, Overijssel, Netherlands

Meander Medisch Centrum /ID# 229608; 🇳🇱 Amersfoort, Utrecht, Netherlands

St. Antonius Ziekenhuis /ID# 229901; 🇳🇱 Nieuwegein, Utrecht, Netherlands

Albert Schweitzer Ziekenhuis /ID# 229560; 🇳🇱 Dordrecht, Zuid-Holland, Netherlands

Leids Universitair Medisch Centrum /ID# 225606; 🇳🇱 Leiden, Zuid-Holland, Netherlands

Haaglanden Medisch Centrum /ID# 229686; 🇳🇱 Den Haag, Netherlands

Deventer Ziekenhuis /ID# 229937; 🇳🇱 Deventer, Netherlands

Universitair Medisch Centrum Groningen /ID# 225602; 🇳🇱 Groningen, Netherlands

Jeroen Bosch Ziekenhuis /ID# 229765; 🇳🇱 S Hertogenbosch, Netherlands

Diakonessenhuis /ID# 251793; 🇳🇱 Utrecht, Netherlands

North Shore Hospital /ID# 250992; 🇳🇿 Takapuna, Auckland, New Zealand

Christchurch Hospital /ID# 250993; 🇳🇿 Christchurch, Canterbury, New Zealand

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka /ID# 228723; 🇵🇱 Slupsk, Pomorskie, Poland

Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 225986; 🇵🇱 Kielce, Swietokrzyskie, Poland

Szpital Kliniczny MSWiA z Warminsko-Mazurskim Centrum Onkologii /ID# 225985; 🇵🇱 Olsztyn, Warminsko-mazurskie, Poland

ARS-MEDICAL Sp. z o.o. /ID# 225848; 🇵🇱 Pila, Wielkopolskie, Poland

Centrum Medyczne Pratia Poznan /ID# 227236; 🇵🇱 Skorzewo, Wielkopolskie, Poland

2CA-Braga, Hospital de Braga /ID# 249112; 🇵🇹 Braga, Portugal

IPO Lisboa FG, EPE /ID# 249109; 🇵🇹 Lisboa, Portugal

IPO Porto FG, EPE /ID# 249110; 🇵🇹 Porto, Portugal

Hospital Erasto Gaertner /ID# 262593; 🇵🇷 Curitiba, Puerto Rico

Hematology and Oncology Institute /ID# 230054; 🇵🇷 Manati, Puerto Rico

Pan American Center for Oncology Trials, LLC /ID# 230052; 🇵🇷 Rio Piedras, Puerto Rico

Narodny onkologicky ustav /ID# 238847; 🇸🇰 Bratislava, Bratislavsky Kraj, Slovakia

Univerzitna nemocnica Martin /ID# 240828; 🇸🇰 Martin, Zilinsky Kraj, Slovakia

Wits Clinical Research /ID# 227799; 🇿🇦 Johannesburg, Gauteng, South Africa

Wits Clinical Research /ID# 227803; 🇿🇦 Johannesburg, Gauteng, South Africa

Alberts Cellular Therapy /ID# 227798; 🇿🇦 Pretoria, Gauteng, South Africa

University of Cape Town /ID# 227802; 🇿🇦 Cape Town, Western Cape, South Africa

Haemalife Inc. /ID# 243391; 🇿🇦 Kuilsrivier, Western Cape, South Africa

Instituto Catalan de Oncologia (ICO) Badalona /ID# 228063; 🇪🇸 Badalona, Barcelona, Spain

Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 227393; 🇪🇸 L'Hospitalet de Llobregat, Barcelona, Spain

Hospital Universitario Reina Sofia /ID# 225806; 🇪🇸 Córdoba, Cordoba, Spain

Hospital Clinico Universitario Virgen de la Arrixaca /ID# 255381; 🇪🇸 El Palmar, Murcia, Spain

Clinica Universidad de Navarra - Pamplona /ID# 225809; 🇪🇸 Pamplona, Navarra, Spain

Hospital Parc de Salut del Mar /ID# 225810; 🇪🇸 Barcelona, Spain

Hospital Universitario Vall d'Hebron /ID# 225811; 🇪🇸 Barcelona, Spain

Hospital Clinic de Barcelona /ID# 226651; 🇪🇸 Barcelona, Spain

Hospital Santa Creu i Sant Pau /ID# 225813; 🇪🇸 Barcelona, Spain

CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 228228; 🇪🇸 Madrid, Spain

Hospital Universitario Infanta Leonor /ID# 225816; 🇪🇸 Madrid, Spain

MD Anderson Madrid /ID# 225817; 🇪🇸 Madrid, Spain

Hospital Universitario Ramon y Cajal /ID# 241750; 🇪🇸 Madrid, Spain

Hospital Universitario Fundacion Jimenez Diaz /ID# 225804; 🇪🇸 Madrid, Spain

Hospital Universitario 12 de Octubre /ID# 225815; 🇪🇸 Madrid, Spain

Hospital Clinico Universitario de Valencia /ID# 225818; 🇪🇸 Valencia, Spain

Linkoping University Hospital /ID# 233521; 🇸🇪 Linkoping, Ostergotlands Lan, Sweden

Skane University Hospital Lund /ID# 227285; 🇸🇪 Lund, Skane Lan, Sweden

Karolinska University Hospital Solna /ID# 229284; 🇸🇪 Solna, Stockholms Lan, Sweden

Sodra Alvsborgs sjukhus /ID# 228885; 🇸🇪 Boras, Vastra Gotalands Lan, Sweden

Sahlgrenska Universitetssjukhuset /ID# 250089; 🇸🇪 Göteborg, Vastra Gotalands Lan, Sweden

Kantonsspital Aarau AG /ID# 229112; 🇨🇭 Aarau, Aargau, Switzerland

Spital Thun /ID# 229499; 🇨🇭 Thun, Bern, Switzerland

KSW Kantonsspital Winterthur /ID# 241631; 🇨🇭 Winterthur, Zuerich, Switzerland

Kaohsiung Chang Gung Memorial Hospital /ID# 226670; 🇨🇳 Kaohsiung City, Kaohsiung, Taiwan

China Medical University Hospital /ID# 226188; 🇨🇳 Taichung, Taiwan

Taichung Veterans General Hospital /ID# 226674; 🇨🇳 Taichung, Taiwan

National Cheng Kung University Hospital /ID# 226671; 🇨🇳 Tainan, Taiwan

Anadolu Saglik Merkezi /ID# 225777; 🇹🇷 Dilovası, Kocaeli, Turkey

Ankara Universitesi Fakultesi /ID# 227331; 🇹🇷 Ankara, Turkey

Inonu University Medical Faculty /ID# 226572; 🇹🇷 Malatya, Turkey

Ondokuz Mayis Universitesi /ID# 251247; 🇹🇷 Samsun, Turkey

Karadeniz University /ID# 226573; 🇹🇷 Trabzon, Turkey

Baskent Universitesi Adana Uyg. ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 225921; 🇹🇷 Yuregir, Turkey

Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 226692; 🇬🇧 Norwich, Norfolk, United Kingdom

University Hospitals Birmingham NHS Foundation Trust /ID# 229197; 🇬🇧 Birmingham, United Kingdom

NHS Lothian /ID# 229055; 🇬🇧 Edinburgh, United Kingdom