Human Single Neuron Recordings in Epilepsy Patients

Not Applicable

• Conditions: Epilepsy; Memory
• Interventions: Diagnostic Test: Microwire electrodes

• Registration Number: NCT04290416
• Lead Sponsor: University of Birmingham

Brief Summary

This study uses single neuron recordings in pre-surgical epilepsy patients to uncover the neural mechanisms underlying memory formation and retrieval. A secondary aim is to improve diagnostic tools to identify epileptogenic tissue.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02-04
• Status Verified: 2019-11
• Study First Submitted: 2019-12-18
• Study First Submitted QC: 2020-02-27
• Last Update Submitted: 2020-02-27
• Study First Posted: 2020-02-28
• Last Update Posted: 2020-02-28
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Interest in participation.
• Temporal lobe epilepsy that is clinically being investigated with implantations of depth electrodes as part of the pre-surgical epilepsy monitoring.
• Cognitive/language skills sufficient to follow experimental instruction and maintain focus on the experiment.

Exclusion Criteria

• Patient does not want to participate.
• Extra-temporal epilepsy, or electrode implantation strategy that does not allow the use of micro-macrowire electrodes.
• Cognitive/language skills insufficient to follow experimental instruction and maintain focus on the experiment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Microwire electrodes	Microwire electrodes	Activity of individual neurons will be recorded via microwire contacts. These microwire electrodes do not interfere with the macrowire clinical recordings.

Primary Outcome Measures

Name	Time	Method
Single unit recordings	14 days (patient in hospital for this length of time)	Activity of individual neurons will be recorded via micro wire electrodes

Secondary Outcome Measures

Name	Time	Method
Intracranial electroencephalogram (iEEG)	14 days (patient in hospital for this length of time)	Secondary outcome measures will be iEEG signals recorded with the macro electrodes, such as: * Event-related potentials; * EEG power and phase of Theta oscillations; * EEG power and phase of Alpha/Beta oscillations; * EEG power and phase of Gamma oscillations; * EEG power of High Frequency Oscillations (\>80 Hz)
Behavioural response data	14 days (patient in hospital for this length of time)	Laptop button presses and corresponding response times will be recorded in MATLAB and presentation file formats. This is acquired at patient's bedside during hospital admission.

Trial Locations

Locations (1)

Queen Elizabeth UHB Hospital; 🇬🇧 Birmingham, West Midlands, United Kingdom