The efficacy of lidocaine in combination with current recommendation for prevention of postoperative nausea and vomiting (PONV) following breast surgery: a prospective randomized controlled trial

Phase 2

• Conditions: Postoperative nausea and vomiting; PONV; Lidocaine; Xylocaine; Mastectomy; Breast surgery

• Registration Number: TCTR20221025004
• Lead Sponsor: Faculty of medicine, Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-25
• Study Completion: 2023-10-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: Female
• Target Recruitment: 134

Inclusion Criteria

Female 18-65 years old
ASA 1-3
Undergoing breast surgery in Srinagarind hospital

Exclusion Criteria

History of smoking
History of anti-emetic drug in 48 hour
Lidocaine allergy
Chronic opioid/anti-cholinergic use
Cirrhosis or abnormal liver function test
Creatinine less than 60
Arrhythmia/AV block/HR less than 50 bpm
Myocardial ischemia
Contraindication for NSAIDs
BMI more than 30

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of PONV 1 hr, 6 hr, 24 hr postoperative Incidence

Secondary Outcome Measures

Name	Time	Method
Severity of PONV 1 hr, 6 hr, 24 hr postoperative Score in percentage (mild,moderate,severe),Total anti-emetic drug consumption 24 hr Average total dose in mg,Total opioid consumption 24 hr Average total dose in mg